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AGO7 protein (Arabidopsis thaliana) - STRING interaction network
"AGO7" - Argonaute family protein in Arabidopsis thaliana
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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AGO7Argonaute family protein; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Required for the processing of 21 nucleotide trans-acting siRNAs (ta-siRNAs) derived from TAS3a transcripts. Associates preferentially with the microRNA (miRNA) miR390 which guides the cleavage of TAS3 precursor RNA. Seem [...] (990 aa)    
Predicted Functional Partners:
DCL4
Dicer-like protein 4; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the biogenesis of trans-acting small interfering RNAs (ta-siRNAs, derived from the TAS1, TAS2 or TAS3 endogenous transcripts) by cleaving small dsRNAs into 21-24 nucleotide ta-siRNAs. Functions with the dsRNA- binding protein DRB4 in ta-siRNAs processing. Acts in the RDR6/SGS3/DCL4/AGO7 ta-siRNA pathway involved in leaf developmental timing. Plays a role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL2 a [...] (1702 aa)
     
 
  0.991
RDR6
RNA-dependent RNA polymerase 6; RNA-dependent RNA polymerase involved in post- transcriptional gene silencing (PTGS). Possesses ssRNA and ssDNA- dependent polymerase activity, but does not have priming activity. Possesses in vitro 3’ nucleotidyltransferase activity in the presence of UTP as single nucleotide. Required for the production of 21 nucleotide trans-acting small interfering RNAs (ta-siRNAs) derived from TAS1, TAS2 and TAS3 endogenous transcripts. Acts in the RDR6/SGS3/DCL4/AGO7 ta-siRNA pathway involved in leaf developmental timing. Required for the production of natural siRN [...] (1196 aa)
     
   
  0.977
SGS3
XS domain-containing protein / XS zinc finger domain-containing protein-related; Required for posttranscriptional gene silencing and natural virus resistance.SGS3 is a member of an ’unknown’ protein family. Members of this family have predicted coiled coiled domains suggesting oligomerization and a potential zinc finger domain. Involved in the production of trans-acting siRNAs, through direct or indirect stabilization of cleavage fragments of the primary ta-siRNA transcript. Acts before RDR6 in this pathway (625 aa)
           
  0.969
DCL2
Endoribonuclease Dicer homolog 2; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of natural small interfering RNAs (nat-siRNAs, derived from cis- natural antisense transcripts) by cleaving small dsRNAs into 24 nucleotide nat-siRNAs. Plays an essential role in transitive silencing of transgenes by processing secondary siRNAs. This pathway, which requires DCL4 and RDR6, amplifies silencing by using the target RNA as substrate to generate secondary siRNAs, providing an efficient mechanism for long-distance silencin [...] (1388 aa)
     
 
  0.966
DCL1
Endoribonuclease Dicer homolog 1; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri- miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of [...] (1910 aa)
     
 
  0.966
AT2G03780
Uncharacterized protein At2g03780/F19B11.23; Translin family protein; Its function is described as sequence-specific DNA binding, DNA binding; Involved in biological_process unknown; Expressed in 22 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Translin, C-terminal (InterPro-IPR016069), Translin (InterPro-IPR002848), Translin, N-terminal (InterPro-IPR016068); Has 561 Blast hits to 561 proteins in 195 species- Archae - 92; Bacteria - 2; Metazoa - 209; Fungi - 153; Plants - 36; Viruses - 0; Other Eukaryotes - 69 (source- NCBI BLink) (287 aa)
       
  0.945
DCL3
Endoribonuclease Dicer homolog 3; Ribonuclease (RNase) III involved in RNA-mediated post- transcriptional gene silencing (PTGS). Involved in the processing of repeat-associated small interfering RNAs (ra-siRNAs, derived from heterochromatin and DNA repeats such as transposons) by cleaving small dsRNAs into 24 nucleotide ra-siRNAs. Plays a role in antiviral RNA silencing. Involved in the production of viral siRNAs derived from the cabbage leaf curl virus (CaLCuV) and tobacco rattle virus (TRV). Targeted by the viral silencing suppressor (VSR) protein 2b of the cucumber mosaic virus (CMV [...] (1580 aa)
     
 
  0.940
AT2G37020
Translin family protein; Its function is described as sequence-specific DNA binding, DNA binding; Involved in biological_process unknown; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- Translin, C-terminal (InterPro-IPR016069), Translin (InterPro-IPR002848), Translin, N-terminal (InterPro-IPR016068) (310 aa)
       
  0.937
RDR2
RNA-dependent RNA polymerase 2; RNA-dependent direct polymerase involved in the production of small interfering RNAs (siRNAs). Required for the biogenesis of endogenous siRNAs of 24 nucleotide which derive from heterochromatin and DNA repeats such as transposons or endogenous gene tandem repeats, such as repeats present in FWA gene. Involved in transcriptional gene silencing (TGS). Component of the RNA- directed DNA methylation (RdDM) silencing pathway that utilizes siRNAs to guide DNA methyltransferases to asymmetric cytosines. Involved in control of flowering time through RdDM of FWA [...] (1133 aa)
     
   
  0.928
AGO6
Argonaute family protein; Involved in transcriptional gene silencing (TGS). Component of the RISC complex that associate with the small interfering RNA (siRNA) pathway involved in direct cytosine methylation at endogenous DNA repeats. Required for the accumulation of specific siRNAs derived from transgene and heterochromatin-related endogenous loci. Involved in RNA-directed DNA methylation (RdDM) at specific endogenous loci. Probably not required for the accumulation of siRNAs derived from transgene inverted repeats that induce post-transcriptional gene silencing (PTGS). Associates mai [...] (878 aa)
         
0.925
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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