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SBH1 protein (Arabidopsis thaliana) - STRING interaction network
"SBH1" - Sphinganine C4-monooxygenase 1 in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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SBH1Sphinganine C4-monooxygenase 1; Encodes one of the two redundant sphingoid base hydroxylases (SBH). Involved in sphingolipid trihydroxy long-chain base (4-hydroxysphinganine) biosynthesis. Double mutants of SBHs were dwarfed and not able to progress from vegetative to reproductive growth; Belongs to the sterol desaturase family (260 aa)    
Predicted Functional Partners:
TSC10A
NAD(P)-binding Rossmann-fold superfamily protein; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Lacks stereospecificity and can also produce L-threo-DHS in addition to D-erythro-DHS; Belongs to the short-chain dehydrogenases/reductases (SDR) family (326 aa)
       
  0.977
TSC10B
NAD(P)-binding Rossmann-fold superfamily protein; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). Required for sphingolipid biosynthesis. In plants, sphingolipids seems to play a critical role in mineral ion homeostasis, most likely through their involvement in the ion transport functionalities of membrane systems in the root. Is stereospecific for D-erythro-DHS production and does not produce L-threo-DHS; Belongs to the short-chain dehydrogenases/reductases (SDR) family (331 aa)
       
  0.971
AT1G07380
Neutral/alkaline non-lysosomal ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Regulates sphingolipid homeostasis. Promotes oxidative stress resistance; Belongs to the neutral ceramidase family (779 aa)
         
  0.963
ATCES1
Alkaline phytoceramidase (aPHC); Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity (By similarity). Affects plant morphogenesis. Required for the formation of wax layer that ensure cuticle permeability. Implicated in abscisic acid (ABA)-mediated stomatal closure. Involved in both biotic and abiotic stresses. Promotes salt resistance and defenses responses toward pathogenic bacteria (e.g. P.syringae) and against the fungal toxin fumonisin B1 (FB1); Belongs to the alkaline ceramidase family (255 aa)
     
  0.960
AT5G58980
Neutral/alkaline non-lysosomal ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid (By similarity). Promotes oxidative stress resistance (733 aa)
         
  0.954
AT2G38010
Neutral/alkaline non-lysosomal ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the neutral ceramidase family (792 aa)
         
  0.953
SPHK1
Sphingosine kinase 1; Involved in the production of sphingolipid metabolites. Phosphorylates sphingosine and various sphingoid long-chain base (LCB) products, such as phytosphingosine (PHS, 4- hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine, D-erythro-dihydrosphingosine and D,L-threo-dihydrosphingosine. Is required for abscisic acid (ABA) signaling that mediates stomatal closure, inhibition of seed germination and root elongation. May function upstream of PLDALPHA1 and phosphatidic acid (PA) in an amplification response to ABA that mediates stomatal closure (485 aa)
     
  0.938
SPHK2
Diacylglycerol kinase family protein; Involved in the production of sphingolipid metabolites. Phosphorylates sphingosine and various l sphingoid long-chain base (LCB) products, such as phytosphingosine (PHS, 4- hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-erythro-dihydrosphingosine, but has a very few activity toward D,L-threo- dihydrosphingosine. Is required for abscisic acid (ABA) signaling that mediates stomatal closure, inhibition of seed germination and root elongation. May function upstream of PLDALPHA1 and phosphatidic acid (PA) in an amplification resp [...] (481 aa)
     
  0.925
DES-1-LIKE
Sphingolipid delta(4)-desaturase DES1-like; Encodes a sphingolipid delta4-desaturase, involved in sphingolipid biosynthesis. Specifically expressed in floral tissues. Knockout mutants were devoid of sphinga-4,8-dienine in floral tissues (332 aa)
     
 
  0.906
FAH2
Dihydroceramide fatty acyl 2-hydroxylase FAH2; Fatty acid 2-hydroxylase involved in the alpha- hydroxylation of the long-chain fatty acid (LCFA) palmitic acid. Probably involved in the resistance response to oxidative stress; Belongs to the sterol desaturase family (237 aa)
     
 
  0.879
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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