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HMG1 protein (Arabidopsis thaliana) - STRING interaction network
"HMG1" - Hydroxy methylglutaryl CoA reductase 1 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Score
HMG1Hydroxy methylglutaryl CoA reductase 1; Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants (642 aa)    
Predicted Functional Partners:
HMGS
HYDROXYMETHYLGLUTARYL-COA SYNTHASE; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Devoided of acetoacetyl-CoA thiolase (AACT) activity. Required for the development of both tapetosomes and elaioplasts in tapetal cells and for pollen viability during pollen tube elongation (461 aa)
   
 
  0.999
MK
Mevalonate kinase (378 aa)
       
  0.995
IPP1
Isopentenyl diphosphate isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (291 aa)
   
   
  0.900
MVD1
Mevalonate diphosphate decarboxylase 1; Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids. Can complement a yeast mutant defective in MVD activity (412 aa)
   
   
  0.874
SQS1
Squalene synthase (410 aa)
   
 
  0.861
FPS1
Farnesyl diphosphate synthase 1; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (384 aa)
   
 
  0.860
SNF4
Sucrose nonfermenting 4-like protein; Regulatory subunit of the probable trimeric SNF1-related protein kinase (SnRK) complex, which may play a role in a signal transduction cascade regulating gene expression and carbohydrate metabolism in higher plants (487 aa)
       
 
  0.810
FPS2
Farnesyl diphosphate synthase 2; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (342 aa)
   
 
  0.810
DEG15
Protease DEG15; Trypsin-like serine endopeptidase involved in the processing of glyoxysomal higher molecular weight precursor. The dimeric form carries out the specific cleavages needed to remove PTS2-containing presequences, whereas the monomeric form degrades the removed presequences and misfolded proteins (Probable). Not required for degradation of glyoxylate cycle enzymes during seedling development (709 aa)
           
  0.809
HMG2
3-hydroxy-3-methylglutaryl-CoA reductase 2; Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants (562 aa)
   
   
0.806
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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