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CAND1 protein (Arabidopsis thaliana) - STRING interaction network
"CAND1" - Arabidopsis thaliana homolog of human CAND1 (cullin-associated and neddylation-dissociated). Putative similarity to TBP-interacting protein TIP120. Ubiquitously expressed in plant tissues throughout development. T-DNA insertion mutant plants were completely sterile and resistant to sirtinol and auxin, but not to gibberellins or brassinolide. Displayed developmental phenotypes similar to those of axr1, namely, short petioles, downwardly curling leaves, shorter inflorescence. Required for SCF function and appears to modulate SCF complex cycling. Physically interacts with CUL1 in Arabidopsis thaliana
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Predicted Interactions
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CAND1Arabidopsis thaliana homolog of human CAND1 (cullin-associated and neddylation-dissociated). Putative similarity to TBP-interacting protein TIP120. Ubiquitously expressed in plant tissues throughout development. T-DNA insertion mutant plants were completely sterile and resistant to sirtinol and auxin, but not to gibberellins or brassinolide. Displayed developmental phenotypes similar to those of axr1, namely, short petioles, downwardly curling leaves, shorter inflorescence. Required for SCF function and appears to modulate SCF complex cycling. Physically interacts with CUL1; Belongs t [...] (1219 aa)    
Predicted Functional Partners:
CUL4
Cullin-4; Component of the CUL4-RBX1-CDD (COP10-DDB1a-DET1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Participates in the CDD complex to light-mediated control of development. May repress photomorphogenesis through enhancing COP1 E3 ubiquitin-protein ligase activity. Acts together with the CUL4- DDB1-COP1-SPA E3 ubiquitin-protein ligase complexes in the repression of photomorphogenesis and flowering time. Component ot the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex which mediates ubiquiti [...] (792 aa)
     
  0.998
CUL1
Cullin-1; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Regulator of mitotic processes which plays a role during gametogenesis and embryogenesis. Together with SKP1, RBX1 and a F-box protein, it forms a SCF complex. The functional specificity of this complex depends of the type of F-box protein. SCF(UFO) is implicated in floral organ development. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1/ZTL), SCF(ADO2/LKP2), SCF(A [...] (738 aa)
     
 
  0.997
AT3G42830
RING/U-box superfamily protein; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The SCF complex plays a crucial role in regulating response to auxin and is essential for growth and development. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, to the complex and brings it into close proximity to the substrate (By similarity); Belongs to the RING-box family (115 aa)
       
  0.995
CUL2
Cullin-2; Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (742 aa)
     
 
  0.978
DDB1A
Damaged DNA binding protein 1A; Component of light signal transduction machinery. Involved in repression of photomorphogenesis in darkness by participating in the CDD complex, a complex probably required to regulate the activity of ubiquitin conjugating enzymes (E2s). Repression of photomorphogenesis is probably mediated by ubiquitination and subsequent degradation of photomorphogenesis- promoting factors such as HY5, HYH and LAF1. Plays a role in DNA repair by forming with DDB2 the UV-damaged DNA-binding protein complex (UV-DDB). Component of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-prote [...] (1088 aa)
     
  0.977
RBX1
Encodes a ring-box 1 like protein and component of the SCF ubiquitinization complex mediating auxin responses. Forms a E3 ubiquitin ligase complex with CUL3A and At1g21780.1 a BTB domain protein (142 aa)
       
 
  0.977
DDB1B
Damaged DNA binding protein 1B; One of two closely related genes similar to a damaged DNA binding protein originally described in mammals. May form a complex with DET1 to regulate photomorphogenesis. Loss of function mutations are lethal. The DDB1b protein binds with a number of DWD-containing proteins and may form part of a CUL4-based E3 ubiquitin ligase (1088 aa)
     
  0.976
CUL3
Cullin-3A; Component of the cullin-RING ubiquitin ligases (CRL), or CUL3-RBX1-BTB protein E3 ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the CRL complex depends on the BTB domain-containing protein as the susbstrate recognition component. Involved in embryo pattern formation and endosperm development. Required for the normal division and organization of the root stem cells and columella root cap cells. Regulates primary root growth by an unknown pathway, but in an ethylene- dependent manner. [...] (732 aa)
     
 
  0.966
AT3G27640
Transducin/WD40 repeat-like superfamily protein; Contains the following InterPro domains- WD40 repeat 2 (InterPro-IPR019782), WD40 repeat, conserved site (InterPro-IPR019775), WD40 repeat (InterPro-IPR001680), G-protein beta WD-40 repeat, region (InterPro-IPR020472), WD40 repeat-like-containing domain (InterPro-IPR011046), WD40-repeat-containing domain (InterPro-IPR017986), WD40/YVTN repeat-like-containing domain (InterPro-IPR015943), WD40 repeat, subgroup (InterPro-IPR019781); BEST Arabidopsis thaliana protein match is- Transducin/WD40 repeat-like superfamily protein (TAIR-AT2G43770.1 [...] (535 aa)
         
  0.951
ARP2
Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. Involved in the control of cell morphogenesis in leaf epidermal pavement cells, root hairs, hypocotyls epidermal cells and trichomes, [...] (389 aa)
     
 
  0.949
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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