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AtPOT1a protein (Arabidopsis thaliana) - STRING interaction network
"AtPOT1a" - Nucleic acid-binding, OB-fold-like protein in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AtPOT1aNucleic acid-binding, OB-fold-like protein; Encodes AtPOT1a, an accessory factor for telomerase required for positive telomere length regulation. Note on nomenclature- different names have been given to Arabidopsis POT-like genes (Kuchar and Fajkus, 2004; Shakirov et al, 2005; Tani and Murata, 2005). According to a unifying nomenclature (Surovtseva et al, 2007), At2g05210 (previously named AtPOT1) is designated AtPOT1a, while At5g06310 (previously named AtPOT2) is designated AtPOT1b; Belongs to the telombin family (467 aa)    
Predicted Functional Partners:
STN1
Nucleic acid-binding, OB-fold-like protein; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Associates with enzymatically active telomerase. Plays a genomewide role in DNA replication and facilitates re- replication at non-telomeric loci (160 aa)
     
 
  0.992
TERT
Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Required to prevent genome instability induced by breakage-fusion-bridge (BFB) cycles. Can extend completely non-telomeric sequences using RNA template in vitro (1123 aa)
       
 
  0.988
CTC1
Conserved telomere maintenance component 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Associates with enzymatically active telomerase (1274 aa)
       
 
  0.986
TRB1
Telomere repeat-binding factor 1; Encodes a telomeric DNA binding protein. In vitro, an N-terminal Myb domain enables it to interact with double-stranded telomeric repeats (300 aa)
       
 
  0.977
NAP57
H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (’psi’) residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family (565 aa)
     
 
  0.975
MDO1
CST complex subunit TEN1; Required for the maintenance of meristems and stem cells through the reduction of DNA damage. Promotes telomere integrity by maintaining telomere length and proper architecture of the chromosome terminus. Negatively regulates telomerase repeat addition processivity. Hampers contacts between enzymatically active telomerase and CST complex; Belongs to the TEN1 family (127 aa)
         
  0.939
TPP
Encodes a thylakoidal processing peptidase that removes signal sequences from proteins synthesized in the cytoplasm and transported into the thylakoid lumen (340 aa)
           
  0.903
At5g59430
Encodes a telomeric repeat binding protein with a DNA binding domain at its C terminus. The DNA binding domain has a preference for GGTTTAG sequences and at least five of these repeats are required for recognition by a nearly full-length TRP1 protein (578 aa)
         
  0.898
KU70
ATP-dependent DNA helicase 2 subunit KU70; Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand; Belongs to the ku70 family (621 aa)
       
 
  0.872
TRB2
Homeodomain-like/winged-helix DNA-binding family protein; Encodes a telomeric DNA binding protein. In vitro, the protein preferentially binds double-stranded telomeric repeats, but it can also bind to the single G-rich telomeric strand; Belongs to the histone H1/H5 family. SMH subfamily (299 aa)
       
 
  0.838
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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