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NERD protein (Arabidopsis thaliana) - STRING interaction network
"NERD" - Nucleic acid binding in Arabidopsis thaliana
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NERDNucleic acid binding;zinc ion binding;DNA binding; Plays a central role in integrating RNA silencing and chromatin signals in 21 nt siRNA-dependent DNA methylation on cytosine pathway leading to transcriptional gene silencing of specific sequences. Involved in a chromatin-based RNA silencing pathway that encompasses both post-transcriptional gene silencing (PTGS) (e.g. RDR1, RDR6 and AGO2) and transcriptional gene silencing (TGS) (e.g. siRNA-dependent DNA methylation and histone H3) components. Mediates siRNA accumulation at specific chromatin loci. Binds H3K4me0 through its PHD to enf [...] (1773 aa)    
Predicted Functional Partners:
AT3G63070
Tudor/PWWP/MBT domain-containing protein; Probable transcription factor that acts with partial redundancy with HULK1 and HULK2. Plays diverse and essential roles in the control of plant development, physiology and flowering time (1347 aa)
     
 
  0.920
HUA2
Tudor/PWWP/MBT domain-containing protein; Transcription factor that functions as repressor of flowering by enhancing the expression of several genes that delay flowering including FLC, FLM/MAF1, MAF2 and SVP. Also acts in the floral homeotic AGAMOUS (AG) pathway, specifically by processing the AGAMOUS pre-mRNA. Functions in association with HUA1 and HEN4 in AG pre-mRNA processing. Involved in all three aspects of the AG functions, the specification of stamen and carpel identities, the control of floral determinacy, and the spatial restriction of AP1 expression. Acts as transcription re [...] (1392 aa)
     
 
  0.915
AT5G08230
Tudor/PWWP/MBT domain-containing protein; Probable transcription factor that acts with partial redundancy with HULK2 and HULK3. Plays diverse and essential roles in the control of plant development, physiology and flowering time (1445 aa)
     
 
  0.912
AT2G48160
Tudor/PWWP/MBT domain-containing protein; Probable transcription factor that acts with partial redundancy with HULK1 and HULK2. Plays diverse and essential roles in the control of plant development, physiology and flowering time (1366 aa)
     
 
  0.912
NCBP
Eukaryotic translation initiation factor NCBP; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (221 aa)
       
 
  0.911
NUA
Nuclear-pore anchor; Encodes a 237-kDA protein with similarity to vertebrate Tpr, a long coiled-coil proteins of nuclear pore inner basket filaments. It is localized to the inner surface of the nuclear envelope and is a component of the nuclear pore-associated steps of sumoylation and mRNA export in plants. Mutations affect flowering time regulation and other developmental processes. Probably acts in the same pathway as ESD4 in affecting flowering time, vegetative and inflorescence development (2115 aa)
     
        0.911
BSH
Transcription regulatory protein SNF5, putative (BSH); Component of a multiprotein complex equivalent of the yeast SWI/SNF complex, an ATP-dependent chromatin-remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors; Belongs to the SNF5 family (242 aa)
     
 
  0.881
AT3G13350
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content (319 aa)
     
 
  0.864
AT1G76110
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content. Required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus (338 aa)
     
 
  0.864
AT1G55650
HMG (high mobility group) box protein with ARID/BRIGHT DNA-binding domain; Binds preferentially DNA with A/T-rich content (337 aa)
     
 
  0.864
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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