STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PHO1Phosphate transporter PHO1; Inositol polyphosphate sensor that associates with transcription factors to regulate inorganic phosphate (Pi) starvation responses. Probably acts by binding inositol polyphosphate via its SPX domain. Acts as a Pi exporter, mediating efflux of Pi out of cells. Transfers Pi from the epidermal and cortical cells to the root xylem vessels. Involved in the transfer of Pi from roots to shoots. Involved in abscisic acid (ABA) induction of stomatal closure and ABA repression of stomatal opening; Belongs to the SYG1 (TC 2.A.94) family (782 aa)    
Predicted Functional Partners:
PHO2
Probable ubiquitin-conjugating enzyme E2 24; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi-sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane
   
 
 0.994
PHT1;1
Encodes an inorganic phosphate transporter Pht1;1. Mutants display enhanced arsenic accumulation. Members of the Pht1 family of phosphate transporters include: Pht1;1/At5g43350, Pht1;2/At5g43370, Pht1;3/At5g43360, Pht1;4/At2g38940, Pht1;5/At2g32830, Pht1;6/At5g43340, Pht1;7/At3g54700, Pht1;8/At1g20860, Pht1;9/At1g76430 (Plant Journal 2002, 31:341)
   
 
 0.936
WRKY6
WRKY family transcription factor; Transcription factor involved in the control of processes related to senescence and pathogen defense. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element. Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes. Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression; Belongs to the WRKY group II-b family
      
 0.868
T5F17.60
Protein PHOSPHATE STARVATION RESPONSE 1; Transcription factor involved in phosphate starvation signaling. Binds as a dimer to P1BS, an imperfect palindromic sequence 5'- GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes. SPX1 is a competitive inhibitor of this DNA- binding. PHR1 binding to its targets is low Pi- dependent. Regulates the expression of miR399. Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions. Regulates lipid remodeling an [...]
      
 0.865
GGH3
Probable gamma-glutamyl hydrolase 3; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content (By similarity)
      
 0.836
GGH1
Gamma-glutamyl hydrolase 1; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role in folate stability and intracellular folate content; Belongs to the peptidase C26 family
      
 0.834
GGH2
Gamma-glutamyl hydrolase 2; Cleaves the polyglutamate sidechains of folate polyglutamates in the vacuole. Is important for polyglutamyl tail length determination before vacuolar exit. Plays a role on folate stability and intracellular folate content. Has endopeptidase activity against 4-amino-10-methylpteroyl penta-, tetra-, tri- and di-gamma-L-glutamate substrates and is responsible for the production of folic acid, also called pteroylglutamic acid (PteGlu) from teroylpolyglutamates; Belongs to the peptidase C26 family
      
 0.834
SPX1
SPX domain-containing protein 1; Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner
      
 0.828
SPX3
SPX domain-containing protein 3; Plays a positive role in plant adaptation to phosphate starvation and exerts negative feedback regulation of SPX1
      
 0.794
SPX2
SPX domain-containing protein 2; May inhibit PHR1 DNA-binding activity in a Pi-dependent manner
      
 0.788
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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