STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPLSporocyteless (spl); Transcriptional regulator of sporocyte development . Acts as an adapter-like transcriptional repressor recruiting TPL/TPR corepressors to inhibit TCP transcription factors . Required for nucellus and embryo sac development . Plays a central role in patterning both the proximal-distal and the adaxial-abaxial axes during ovule development . Involved in establishing the prospective chalaza of the ovule and in controlling the cell number and the length of the funiculus, and is required for the development of the integuments . Required, with BEL1, for cytokinin-induced [...] (314 aa)    
Predicted Functional Partners:
INO
Essential for formation and asymmetric growth of the ovule outer integument. Member of the YABBY protein family of putative transcription factors that contain apparent Cys(2)-Cys(2) zinc-finger domains and regions of similarity to the high mobility group (HMG) transcription factors. INO may be required for polarity determination in the central part of the ovule
   
 
 0.929
DYT1
Basic helix-loop-helix (bHLH) DNA-binding superfamily protein; Encodes a bHLH transcription factor strongly expressed in the tapetum from late anther stage 5 to early stage 6, and at a lower level in meiocytes. dyt1 mutant exhibits abnormal anther morphology beginning at anther stage 4. DYT1 acts downstream of SPL/NZZ and EMS1/EXS , and is required for normal expression of AMS, MS1 and other tapetum preferential genes
   
  
 0.902
EMS1
Leucine-rich repeat transmembrane protein kinase; Receptor with a serine/threonine-protein kinase activity required for the specification of the correct number of male archesporial initials and for the subsequent specification of tapetal and middle cell layer identities. In seeds, required for enhancing cell size and the rate of embryonic development
      
 0.901
TCP5
TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 5; Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary- specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment
    
 
 0.879
MS1
RING/FYVE/PHD zinc finger superfamily protein; Transcriptional activator required for anther and post- meiotic pollen development and maturation. Seems to regulate inflorescence branching and floral development. May control tapetal development by directly regulating tapetal programmed cell death (PCD) and breakdown. Implicated in pollen cytosolic components and wall development (e.g. exine and intine formation)
   
  
 0.871
TDF1
Defective in meristem development and function 1; Required for anther development and early tapetal function during microspore maturation . Regulates callose dissolution required for microspores release from the tetrads
      
 0.852
TCP3
Encodes a member of a recently identified plant transcription factor family that includes Teosinte branched 1, Cycloidea 1, and proliferating cell nuclear antigen (PCNA) factors, PCF1 and 2. Regulated by miR319. Involved in heterchronic regulation of leaf differentiation
    
 
 0.850
TPL
Transducin family protein / WD-40 repeat family protein; Encodes a protein with several WD40 repeats at the C-terminus and predicted protein-protein interaction domains at the N-terminus. Together with the TOPLESS-RELATED PROTEINS (TPRs), it is thought to be involved in transcriptional repression of root-promoting genes in the top help of the embryo during the transition stage of embryogenesis. The ability of IAA12 to repress transcription is diminished in a tpl-1 mutant background
    
 
 0.842
TPD1
Protein TAPETUM DETERMINANT 1; Encodes a novel small protein which is similar to proteins of unknown function from other plant species. TPD1 is involved in cell specification during anther and pollen development. Identified in a screen for male steriles. Mutants lack tapetal cells and have an increased number of microsporocytes. Expressed in flower buds, leaves and young seedlings. In anthers, TPD1 is expressed throughout pollen development in parietal cells and sporocytes. Physically interacts with the LRR kinase EMS1 and that interaction results in phosphorylation of TPD1
      
 0.837
TCP2
TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 2; Plays a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary- specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164). Participates in ovule develpment. Participates in ovule develpment. Promotes light-regulated transcription of CHS, CAB, HYH and HY5. Regulates positively photomorphogenesis (e.g. hypocotyl elongation inhibition and cotyledon opening in response to blue light)
    
 
 0.823
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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