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PDK1 protein (Arabidopsis thaliana) - STRING interaction network
"PDK1" - 3'-phosphoinositide-dependent protein kinase 1 in Arabidopsis thaliana
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PDK13’-phosphoinositide-dependent protein kinase 1; May couple lipid signals to the activation-loop phosphorylation of several protein kinases of the so-called AGC kinase family. Interacts via its pleckstrin homology domain with phosphatidic acid, PtdIns3P and PtdIns(3,4)P2 and to a lesser extent with PtdIns(4,5)P2 and PtdIns4P. May play a general role in signaling processes controlling the pathogen/stress response, polar auxin transport and development. Transphosphorylates the AGC protein kinases OXI1/AGC2-1, PK1/S6K1, PK19/S6K2 and PID resulting in their activation (491 aa)    
Predicted Functional Partners:
S6K2
Serine/threonine-protein kinase AtPK2/AtPK19; Encodes a ribosomal-protein S6 kinase. Gene expression is induced by cold and salt (NaCl). Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Phosphorylates specifically mammalian and plant S6 at 25 degrees C but not at 37 degrees C. Involved in translational up-regulation of ribosomal proteins; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily (471 aa)
   
0.987
PK1
Serine/threonine-protein kinase AtPK1/AtPK6; Encodes a protein-serine kinase that phosphorylates ribosomal protein in vitro. Activation of AtS6k is regulated by 1-naphthylacetic acid and kinetin, at least in part, via a lipid kinase-dependent pathway. Involved in translational up-regulation of ribosomal proteins. Phosphorylated by PDK1. Interacts with RAPTOR1, which in turn interacts with TOR. SPK6 activity is affected by osmotic stress, and plants overexpressing S6k1 are hypersensitive to osmotic stress. The gene is expressed in all tissues examined, with highest expression level det [...] (465 aa)
   
0.986
PDK
[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Pyruvate dehydrogenase kinase (PDK) specifically phosphorylates the E1α subunit of the pyruvate dehydrogenase complex (PDC) on a Ser residue using ATP as a phosphate donor. PDK is a unique type of protein kinase having a His-kinase-like sequence but Ser-kinase activity. Site-directed mutagenesis and structural analysis indicate that PDK belongs to the GHKL superfamily (366 aa)
       
 
  0.905
AT3G10540
3-phosphoinositide-dependent protein kinase; Its function is described as kinase activity; Involved in protein amino acid phosphorylation; Located in plasma membrane; Expressed in 24 plant structures; Expressed during 15 growth stages; Contains the following InterPro domains- Serine/threonine-protein kinase domain (InterPro-IPR002290), Serine/threonine-protein kinase-like domain (InterPro-IPR017442), Protein kinase-like domain (InterPro-IPR011009), Serine/threonine-protein kinase, active site (InterPro-IPR008271), Serine/threonine-protein kinase-1, 3-phosphoinositide dependent (InterPr [...] (486 aa)
   
   
0.901
TOR
Serine/threonine-protein kinase TOR; Essential cell growth regulator that controls development from early embryo to seed production. Controls plant growth in environmental stress conditions. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy. Can phosphorylate TAP46, a regulatory subunit of protein phosphatase 2A that modulates cell growth and survival. Involved in modulating the transition from heterotrophic [...] (2481 aa)
     
 
  0.900
AGC2-1
AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein; Involved in oxidative burst-mediated signaling. Required for basal resistance to P.parasitica infection and root hair growth. Partly required for the activation of MPK3 and MPK6 by hydrogen peroxide and cellulase elicitor; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family (421 aa)
   
 
 
0.843
PID
Encodes a protein serine/threonine kinase that may act as a positive regulator of cellular auxin efflux, as a a binary switch for PIN polarity, and as a negative regulator of auxin signaling. Recessive mutants exhibit similar phenotypes as pin-formed mutants in flowers and inflorescence but distinct phenotypes in cotyledons and leaves. Expressed in the vascular tissue proximal to root and shoot meristems, shoot apex, and embryos. Expression is induced by auxin. Overexpression of the gene results in phenotypes in the root and shoot similar to those found in auxin-insensitive mutants. Th [...] (438 aa)
       
 
0.803
EMB3010
40S ribosomal protein S6-2; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (249 aa)
           
  0.776
RPS6A
40S ribosomal protein S6-1; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (250 aa)
           
  0.753
AT1G61575
Serine/Threonine kinase kinase ATP-binding sugar-binding kinase carbohydrate-binding protein; Unknown protein; Has 4 Blast hits to 4 proteins in 1 species- Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 4; Viruses - 0; Other Eukaryotes - 0 (source- NCBI BLink) (52 aa)
           
  0.693
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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