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DEL2 protein (Arabidopsis thaliana) - STRING interaction network
"DEL2" - E2F transcription factor-like E2FD in Arabidopsis thaliana
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Predicted Interactions
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textmining
co-expression
protein homology
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DEL2E2F transcription factor-like E2FD; Inhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway; Belongs to the E2F/DP family (359 aa)    
Predicted Functional Partners:
RBR1
Retinoblastoma-related protein 1; Key regulator of entry into cell division. Acts as a transcription repressor of E2F target genes, whose activity is required for progress from the G1 to the S phase of the cell cycle. Hyperphosphorylation by CDKA-1 prevents the binding to E2F transcription factors, allowing G1 to S phase transition to operate. Forms a stable complex with E2FA that functions in maintaining cell proliferation through repression of cell differentiation. Plays a central role in the mechanism controlling meristem cell differentiation, cell fate establishment and cell fate m [...] (1013 aa)
     
 
  0.963
DPB
Transcription factor-like protein DPB; Involved in the regulation of the G1/S transition. Increases the DNA binding activity of E2F proteins after heterodimerization. The complex DPB/E2FC restricts cell division and lateral root initiation and may function as a negative regulator of E2F-regulated genes. The interaction with SKP2A is controlled by auxin (385 aa)
     
 
  0.941
DEL1
E2F transcription factor-like E2FE; Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication (403 aa)
         
0.911
DPA
Transcription factor-like protein DPA; Involved in the regulation of the G1/S transition. Increases the DNA binding and the transactivation activities of E2F proteins after heterodimerization. The complex DPA/E2FA promotes cell division and acts as a regulator of the endocycle. Positively regulates the activity of S phase-specific genes; Belongs to the E2F/DP family (292 aa)
     
 
  0.907
DEL3
E2F transcription factor-like E2FF; Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells (354 aa)
         
0.904
MCM3
Minichromosome maintenance (MCM2/3/5) family protein; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells (776 aa)
     
 
  0.651
AT4G21820
Binding;calmodulin binding; Its function is described as calmodulin binding, binding; Located in chloroplast; Expressed in 13 plant structures; Expressed during 6 growth stages; Contains the following InterPro domains- Calponin-homology (InterPro-IPR016146), Armadillo (InterPro-IPR000225), Calponin-like actin-binding (InterPro-IPR001715), Armadillo-type fold (InterPro-IPR016024), IQ calmodulin-binding region (InterPro-IPR000048); BEST Arabidopsis thaliana protein match is- myosin 2 (TAIR-AT5G43900.1); Has 3955 Blast hits to 2210 proteins in 242 species- Archae - 0; Bacteria - 4; Metazo [...] (1255 aa)
     
   
  0.648
AT2G21550
Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (492 aa)
     
   
  0.585
THY-2
Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (565 aa)
     
   
  0.583
THY-1
Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (519 aa)
     
   
  0.580
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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