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AT5G32470 protein (Arabidopsis thaliana) - STRING interaction network
"AT5G32470" - Bifunctional TH2 protein, mitochondrial in Arabidopsis thaliana
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experimentally determined
Predicted Interactions
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textmining
co-expression
protein homology
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AT5G32470Bifunctional TH2 protein, mitochondrial; May be involved in the salvage of thiamine breakdown products. This protein has a haloacid dehalogenase family domain fused to its TenA domain. Phosphatase with the highest activity against thiamine monophosphate (ThMP) and, with a lower activity, against thiamine diphosphate (ThDP), flavin mononucleotide, inorganic pyrophosphate, CTP and dATP. Has a thiamine salvage hydrolase activity, but only against 4-amino-5- aminomethyl-2-methylpyrimidine (amino-HMP) and not against N- formylamino-HMP, desthiothiamine, thiamine, ThMP, and ThDP (617 aa)    
Predicted Functional Partners:
TH1
Encodes a bifunctional enzyme required for thiamine (vitamin B1) biosynthesis. TH1 can phosphorylate HMP-P to produce HMP-PP, the pyrimidine heterocyclic subunit of thiamine. TH1 also catalyzes the condensation of HMP-PP and HET to form thiamine monophosphate (TMP). TH1 also appears capable of phosphorylating HMP based on E.coli mutant complementation assays. th1 mutants are thiamine auxotrophs that die as seedlings on unsupplemented media (522 aa)
 
   
  0.905
THIC
Phosphomethylpyrimidine synthase, chloroplastic; Encodes a protein involved in thiamin biosynthesis. The protein is an iron-sulfur cluster protein predicted to catalyze the conversion of 5-aminoimidazole ribonucleotide (AIR) to hydroxymethylpyrimidine (HMP) or hydroxymethylpyrimidine phosphate (HMP-P). A severe reduction of THIC levels in plants decreases vitamin B1 (thiamin diphosphate (TPP)) levels and also leads to changes in the levels of numerous other metabolites since so many primary metabolic enzymes require a TPP co-factor. thiC mutants are chlorotic and arrest in their devel [...] (644 aa)
         
  0.880
AT3G24030
Hydroxyethylthiazole kinase family protein; Thiazole kinase involved in thiamine salvage pathway (276 aa)
   
   
  0.875
NUDT20
Nudix hydrolase 20, chloroplastic; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (374 aa)
         
  0.840
NUDT24
Nudix hydrolase 24, chloroplastic; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (365 aa)
         
  0.838
AT3G16990
Haem oxygenase-like, multi-helical; Involved in thiamine salvage by hydrolyzing the thiamine breakdown product 4-amino-5-aminomethyl-2-methylpyrimidine (amino- HMP) to 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP). Has a high formylamino-HMP amidohydrolase activity. No activity with other thiamine degradation products such as thiamine mono- or diphosphate, oxothiamine, oxythiamine, thiamine disulfide, desthiothiamine or thiochrome as substrates. Does not display thiaminase II activity, as it is unable to hydrolyze thiamine. Is able to carry out two successive steps in the salvage of [...] (221 aa)
           
  0.777
AT3G21390
Mitochondrial substrate carrier family protein; Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria (335 aa)
           
  0.775
AT3G28430
Unknown protein; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in mitochondrion; Expressed in 17 plant structures; Expressed during 6 growth stages; Contains the following InterPro domains- Protein of unknown function FPL (InterPro-IPR019155); Has 243 Blast hits to 233 proteins in 101 species- Archae - 0; Bacteria - 0; Metazoa - 110; Fungi - 0; Plants - 53; Viruses - 0; Other Eukaryotes - 80 (source- NCBI BLink) (837 aa)
           
  0.761
COG0212
5-formyltetrahydrofolate cyclo-ligase-like protein COG0212; May be involved in thiamine metabolism. Does not possess 5-formyltetrahydrofolate cyclo-ligase activity in vitro (354 aa)
           
  0.745
AT5G48970
Mitochondrial substrate carrier family protein; Mitochondrial transporter that mediates uptake of thiamine diphosphate (ThDP) into mitochondria (339 aa)
           
  0.700
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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