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SEF protein (Arabidopsis thaliana) - STRING interaction network
"SEF" - HIT-type Zinc finger family protein in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
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gene co-occurrence
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textmining
co-expression
protein homology
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SEFHIT-type Zinc finger family protein; Encodes SERRATED LEAVES AND EARLY FLOWERING (SEF), an Arabidopsis homolog of the yeast SWC6 protein, a conserved subunit of the SWR1/SRCAP complex. SEF loss-of-function mutants have a pleiotropic phenotype characterized by serrated leaves, frequent absence of inflorescence internodes, bushy aspect, and flowers with altered number and size of organs. sef plants flower earlier than wild-type plants both under inductive and non-inductive photoperiods. SEF, ARP6 and PIE1 might form a molecular complex in Arabidopsis related to the SWR1/SRCAP complex ide [...] (171 aa)    
Predicted Functional Partners:
PIE1
Encodes a protein similar to ATP-dependent, chromatin-remodeling proteins of the ISWI and SWI2/SNF2 family. Genetic analyses suggest that this gene is involved in multiple flowering pathways. Mutations in PIE1 results in suppression of FLC-mediated delay of flowering and causes early flowering in noninductive photoperiods independently of FLC. PIE1 is required for expression of FLC in the shoot apex but not in the root.Along with ARP6 forms a complex to deposit modified histone H2A.Z at several loci within the genome. This modification alters the expression of the target genes (i.e. FL [...] (2055 aa)
       
 
  0.994
SWC2
Sequence-specific DNA binding transcription factors;DNA binding;DNA binding; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling (365 aa)
       
 
  0.990
ARP6
Encodes ACTIN-RELATED PROTEIN6 (ARP6), a putative component of a chromatin-remodeling complex. Required for both histone acetylation and methylation of the FLC chromatin in Arabidopsis. Along with PIE1 forms a complex to deposit modified histone H2A.Z at several loci within the genome. This modification alters the expression of the target genes (i.e. FLC, MAF4, MAF6). Incorporation of this variant histone into chromatin mediates the ambient temperature response. Located at specific regions of the nuclear periphery. Expression throughout plants shown by in-situ and immunolocalization [...] (421 aa)
       
 
  0.989
HTA9
Probable histone H2A variant 3; Variant histones H2A are synthesized throughout the cell cycle and are very different from classical S-phase regulated H2A. May replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone co [...] (134 aa)
     
 
  0.965
RIN1
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. Has single-stranded DNA- stimulated ATPase and ATP-dependent DNA helicase (3’ to 5’) activity suggesting a role in nuclear processes such as recombination and transcription (By si [...] (458 aa)
     
  0.960
HTA11
Histone H2A variant 1; Variant histone H2A which may replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) (136 aa)
       
 
  0.958
AT2G47210
Myb-like transcription factor family protein; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A (441 aa)
     
  0.943
AT5G67630
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Its function is described as DNA helicase activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; Located in nucleolus, chloroplast; Expressed in 21 plant structures; Expressed during 13 growth stages; Contains the following InterPro domains- TIP49, C-terminal (InterPro-IPR010339), ATPase, AAA+ type, core (InterPro-IPR003593); BEST Arabidopsis thaliana protein match is- P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR-AT3G49830.1); Has 1807 Blast hits to 1807 p [...] (469 aa)
     
 
  0.910
AT3G49830
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Its function is described as DNA helicase activity, nucleoside-triphosphatase activity, nucleotide binding, ATP binding; Involved in biological_process unknown; Located in chloroplast; Expressed in flower; Expressed during petal differentiation and expansion stage; Contains the following InterPro domains- TIP49, C-terminal (InterPro-IPR010339), ATPase, AAA+ type, core (InterPro-IPR003593); BEST Arabidopsis thaliana protein match is- P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR-AT [...] (473 aa)
     
 
  0.910
ARP4
Actin-related protein 4; Encodes a gene similar to actin-related proteins in other organisms. Member of nuclear ARP family of genes. Component of chromatin remodeling complexes, involved in chromatin-mediated gene regulation. Phenotype of the arp4-1 mutant allele revealed partial sterility due to defects in anther development. Targeting the distinct, 3’ UTR of AtARP4 transcripts with RNA interference caused a drastic reduction in the level of AtARP4 protein expression, and resulted in strong pleiotropic phenotypes such as altered organization of plant organs, early flowering, delayed [...] (441 aa)
       
 
  0.846
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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