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GLA1 protein (Arabidopsis thaliana) - STRING interaction network
"GLA1" - Folylpolyglutamate synthetase family protein in Arabidopsis thaliana
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Predicted Interactions
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GLA1Folylpolyglutamate synthetase family protein; Conversion of folates to polyglutamate derivatives, including tetrahydrofolate. Required during embryogenesis; from maternal tissues until the globular stage, and from the embryo after the globular stage (530 aa)    
Predicted Functional Partners:
AT1G69190
Encodes a bifunctional cytosolic hydroxymethyldihydropterin pyrophosphokinase/ dihydropteroate synthase (HPPK/DHPS)that is involved in tetrahydrofolate biosynthesis and is responsive to oxidative stress (484 aa)
 
 
  0.990
AT4G30000
Dihydropterin pyrophosphokinase / Dihydropteroate synthase; Catalyzes the first two consecutive steps of tetrahydrofolate biosynthesis; In the N-terminal section; belongs to the HPPK family (561 aa)
 
 
  0.987
THY-2
Bifunctional dihydrofolate reductase-thymidylate synthase 2; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (565 aa)
   
 
  0.979
THY-1
Bifunctional dihydrofolate reductase-thymidylate synthase 1; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Can play two different roles depending on the source of dihydrofolate- de novo synthesis of tetrahydrofolate or recycling of the dihydrofolate released as one of the end products of the TS catalyzed reaction. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP; In the C-terminal section; belongs to the thymidylate synthase family (519 aa)
   
 
  0.979
FOLB2
Dihydroneopterin aldolase 2; Catalyzes the conversion of 7,8-dihydroneopterin into 6- hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate. Can use L-threo-dihydroneopterin and D- erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2’ of dihydroneopterin and dihydromonapterin (131 aa)
         
  0.973
FOLB3
Probable dihydroneopterin aldolase 3; Catalyzes the conversion of 7,8-dihydroneopterin into 6- hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate. Can use L-threo-dihydroneopterin and D- erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2’ of dihydroneopterin and dihydromonapterin; Belongs to the DHNA family (160 aa)
         
  0.970
FOLB1
Dihydroneopterin aldolase 1; Catalyzes the conversion of 7,8-dihydroneopterin into 6- hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate. Can use L-threo-dihydroneopterin and D- erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2’ of dihydroneopterin and dihydromonapterin (146 aa)
         
  0.970
AT3G07270
GTP cyclohydrolase 1; GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid (466 aa)
   
   
  0.948
ADCL
D-aminoacid aminotransferase-like PLP-dependent enzymes superfamily protein; Amino acid aminotransferase showing activity for D-Asp and D-Ala as amino donors with 2-oxoglutarate as an amino acceptor. Can also use D-Met, D-Tyr, D-Phe, D-Gln, D-Trp and D-Asn as substrates, but no activity with L-Asp, L-Ala, L-Leu, L-Ile or L-Val. Catalyzes also the reverse reaction where an amino group is transferred from D-Glu to pyruvate or oxaloacetate to produce D- Ala or D-Asp, respectively. Also involved in folate biosynthesis, acting as an aminodeoxychorismate lyase converting 4-amino-4- deoxychor [...] (373 aa)
   
 
  0.930
emb1997
Para-aminobenzoate (PABA) synthase family protein; Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity (919 aa)
   
   
  0.915
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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