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AT5G62440 protein (Arabidopsis thaliana) - STRING interaction network
"AT5G62440" - Protein of unknown function in Arabidopsis thaliana
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AT5G62440Protein of unknown function (DUF3223); Encodes a protein DOMINO1 that belongs to a plant-specific gene family sharing a common motif present in the tomato DEFECTIVE CHLOROPLASTS AND LEAVES (LeDCL) protein. DOMINO1 is located in the nucleus. Arabidopsis embryos carrying the domino1 mutation grow slowly in comparison with wild type embryos and reach only the globular stage at desiccation. The primary defect of the mutation at the cellular level is the large size of the nucleolus that can be observed soon after fertilization in the nuclei of both the embryo and the endosperm. DOMINO1 m [...] (202 aa)    
Predicted Functional Partners:
FIB2
Mediator of RNA polymerase II transcription subunit 36a; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and the genera [...] (320 aa)
     
        0.969
AT4G15770
60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly (187 aa)
     
        0.946
FIB1
Probable mediator of RNA polymerase II transcription subunit 36b; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre- initiation complex with RNA polymerase II and t [...] (308 aa)
     
        0.921
RPL3P
50S ribosomal protein L3-2, chloroplastic; One of the primary rRNA binding proteins, it binds directly near the 3’-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (324 aa)
     
        0.918
AT3G59650
Mitochondrial ribosomal protein L51/S25/CI-B8 family protein; Its function is described as molecular_function unknown; Involved in biological_process unknown; Located in mitochondrion; Expressed in 21 plant structures; Expressed during 12 growth stages; Contains the following InterPro domains- Ribosomal protein/NADH dehydrogenase domain (InterPro-IPR007741) (146 aa)
     
        0.917
AT5G52490
Putative rRNA 2’-O-methyltransferase fibrillarin 3; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L- methionine to catalyze the site-specific 2’-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methyl [...] (292 aa)
     
        0.886
AT4G22720
Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity (353 aa)
     
        0.876
ZEU1
P-loop containing nucleoside triphosphate hydrolases superfamily protein; Encodes thymidylate kinase which exists in two isoforms in plants. The longer variant of 263 amino acids with a N-terminal extension that is required for localization to the mitochondrion. The second isoform of 224 residues is localized to the cytoplasm and nucleoplasm. Peak of expression occurs during G1/S phase transition (271 aa)
     
   
  0.868
AT1G52930
Ribosomal RNA processing Brix domain protein; Involved in pre-rRNA processing and required for biogenesis of the large (60S) ribosomal subunit. Required for proper development; Belongs to the BRX1 family (320 aa)
     
        0.841
HD2B
Histone deacetylase HDT2; Encodes a member of a plant-specific class of histone deacetylases. Controls the development of adaxial/abaxial leaf polarity. Its mRNA is widely expressed in stems, leaves, flowers and young siliques. Plant lines expressing RNAi constructs directed against this gene showed a marked reduction in agrobacterium-mediated root transformation (306 aa)
     
        0.826
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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