node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | BCc_068 | BCc_066 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | 0.999 |
hisA | hisC | BCc_068 | BCc_065 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Histidinol-phosphate aminotransferase; COG_category E;COG_number COG0079; HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.992 |
hisA | hisD | BCc_068 | BCc_064 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.995 |
hisA | hisF | BCc_068 | BCc_069 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | BCc_068 | BCc_063 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.989 |
hisA | hisH | BCc_068 | BCc_067 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BCc_068 | BCc_070 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | metG | BCc_068 | BCc_072 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | methionyl-tRNA synthetase; COG_category J;COG_number COG0143; MetG; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.761 |
hisA | pheA | BCc_068 | BCc_244 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Bifunctional chorismate mutase P/prephenate dehydratase; COG_category E;COG_number COG0077, COG1605; mutase N-terminal domain and dehydratase C-terminal domain; PheA. | 0.767 |
hisA | thrA | BCc_068 | BCc_127 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | Aspartokinase I / homoserine dehydrogenase I; COG_category E;COG_number COG0460, COG0527; ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.773 |
hisB | hisA | BCc_066 | BCc_068 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COG_category E;COG_number COG0106; HisA. | 0.999 |
hisB | hisC | BCc_066 | BCc_065 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol-phosphate aminotransferase; COG_category E;COG_number COG0079; HisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BCc_066 | BCc_064 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | BCc_066 | BCc_069 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | BCc_066 | BCc_063 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
hisB | hisH | BCc_066 | BCc_067 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | BCc_066 | BCc_070 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase; COG_category E;COG_number COG0139, COG0140; HisI; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | metG | BCc_066 | BCc_072 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | methionyl-tRNA synthetase; COG_category J;COG_number COG0143; MetG; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.689 |
hisB | pheA | BCc_066 | BCc_244 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Bifunctional chorismate mutase P/prephenate dehydratase; COG_category E;COG_number COG0077, COG1605; mutase N-terminal domain and dehydratase C-terminal domain; PheA. | 0.869 |
hisB | thrA | BCc_066 | BCc_127 | Imidazoleglycerol-phosphate dehydratase; COG_category E;COG_number COG0131, COG0241; HisB; In the N-terminal section; belongs to the histidinol- phosphatase family. | Aspartokinase I / homoserine dehydrogenase I; COG_category E;COG_number COG0460, COG0527; ThrA; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.932 |