node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACL69454.1 | guaA | Hore_06970 | Hore_02020 | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.623 |
ACL69454.1 | guaB | Hore_06970 | Hore_20480 | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.605 |
ACL69454.1 | purH | Hore_06970 | Hore_22090 | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.548 |
ACL69454.1 | pyrR | Hore_06970 | Hore_09350 | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.913 |
ACL69454.1 | surE | Hore_06970 | Hore_08830 | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.921 |
adk | guaA | Hore_01370 | Hore_02020 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.649 |
adk | guaB | Hore_01370 | Hore_20480 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.563 |
adk | purH | Hore_01370 | Hore_22090 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.425 |
adk | pyrH | Hore_01370 | Hore_07670 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.567 |
adk | surE | Hore_01370 | Hore_08830 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.914 |
cinA | guaA | Hore_11920 | Hore_02020 | Competence/damage-inducible protein CinA; PFAM: Competence-damaged protein; Probable molybdopterin binding domain; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain; competence/damage-inducible protein CinA N-terminal domain. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.422 |
cinA | surE | Hore_11920 | Hore_08830 | Competence/damage-inducible protein CinA; PFAM: Competence-damaged protein; Probable molybdopterin binding domain; TIGRFAM: competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain; competence/damage-inducible protein CinA N-terminal domain. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.928 |
cmk | guaA | Hore_10390 | Hore_02020 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.622 |
cmk | guaB | Hore_10390 | Hore_20480 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.618 |
cmk | purH | Hore_10390 | Hore_22090 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.410 |
cmk | pyrF | Hore_10390 | Hore_09390 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.412 |
cmk | pyrH | Hore_10390 | Hore_07670 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.578 |
cmk | pyrR | Hore_10390 | Hore_09350 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | Uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.684 |
cmk | surE | Hore_10390 | Hore_08830 | PFAM: Cytidylate kinase; Shikimate kinase; TIGRFAM: cytidylate kinase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.937 |
guaA | ACL69454.1 | Hore_02020 | Hore_06970 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b domain; Glycosyl transferase family, helical bundle domain; TIGRFAM: thymidine phosphorylase; pyrimidine-nucleoside phosphorylase. | 0.623 |