node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACL68990.1 | mfd | Hore_02290 | Hore_21200 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.404 |
ACL68990.1 | mutL | Hore_02290 | Hore_11660 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.852 |
ACL68990.1 | polA | Hore_02290 | Hore_04860 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.830 |
ACL68990.1 | recA | Hore_02290 | Hore_11890 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.877 |
ACL68990.1 | recR | Hore_02290 | Hore_20770 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.711 |
ACL68990.1 | topA | Hore_02290 | Hore_07540 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.865 |
ACL68990.1 | uvrA | Hore_02290 | Hore_16220 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.657 |
ACL68990.1 | uvrB | Hore_02290 | Hore_16230 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.886 |
ACL68990.1 | uvrC | Hore_02290 | Hore_16210 | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.782 |
dnaK | mutL | Hore_12800 | Hore_11660 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.453 |
dnaK | polA | Hore_12800 | Hore_04860 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.640 |
dnaK | recA | Hore_12800 | Hore_11890 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.628 |
dnaK | recR | Hore_12800 | Hore_20770 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.423 |
dnaK | topA | Hore_12800 | Hore_07540 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.605 |
dnaK | uvrA | Hore_12800 | Hore_16220 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.633 |
dnaK | uvrB | Hore_12800 | Hore_16230 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.574 |
dnaK | uvrC | Hore_12800 | Hore_16210 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.507 |
mfd | ACL68990.1 | Hore_21200 | Hore_02290 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | PFAM: UvrD/REP helicase; TIGRFAM: ATP-dependent DNA helicase PcrA. | 0.404 |
mfd | mutL | Hore_21200 | Hore_11660 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.576 |
mfd | polA | Hore_21200 | Hore_04860 | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.663 |