node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACL69404.1 | ACL70848.1 | Hore_06470 | Hore_21030 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | 0.890 |
ACL69404.1 | ACL70874.1 | Hore_06470 | Hore_21290 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | PFAM: Glutamine synthetase, beta-Grasp domain; Glutamine synthetase, catalytic domain; TIGRFAM: glutamine synthetase, type I. | 0.939 |
ACL69404.1 | gcvH | Hore_06470 | Hore_23430 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.800 |
ACL69404.1 | gcvPA | Hore_06470 | Hore_23420 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.802 |
ACL69404.1 | gcvPB | Hore_06470 | Hore_23410 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.802 |
ACL69404.1 | gcvT | Hore_06470 | Hore_23440 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.807 |
ACL69404.1 | purQ | Hore_06470 | Hore_22140 | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
ACL69773.1 | gcvPA | Hore_10170 | Hore_23420 | PFAM: Patatin-like phospholipase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.531 |
ACL69773.1 | gcvPB | Hore_10170 | Hore_23410 | PFAM: Patatin-like phospholipase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.605 |
ACL70741.1 | gcvPA | Hore_19940 | Hore_23420 | Threonine aldolase; PFAM: Aminotransferase class-V; Aminotransferase class I and II; Beta-eliminating lyase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.918 |
ACL70741.1 | gcvPB | Hore_19940 | Hore_23410 | Threonine aldolase; PFAM: Aminotransferase class-V; Aminotransferase class I and II; Beta-eliminating lyase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.920 |
ACL70741.1 | glyA | Hore_19940 | Hore_16130 | Threonine aldolase; PFAM: Aminotransferase class-V; Aminotransferase class I and II; Beta-eliminating lyase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
ACL70848.1 | ACL69404.1 | Hore_21030 | Hore_06470 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glutamate synthase (NADPH) small subunit; PFAM: Thi4 family; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Flavin containing amine oxidoreductase; FAD dependent oxidoreductase; FAD binding domain; FAD binding domain; HI0933-like protein; TIGRFAM: glutamate synthase (NADPH), homotetrameric. | 0.890 |
ACL70848.1 | ACL70874.1 | Hore_21030 | Hore_21290 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | PFAM: Glutamine synthetase, beta-Grasp domain; Glutamine synthetase, catalytic domain; TIGRFAM: glutamine synthetase, type I. | 0.931 |
ACL70848.1 | gcvH | Hore_21030 | Hore_23430 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
ACL70848.1 | gcvPA | Hore_21030 | Hore_23420 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.972 |
ACL70848.1 | gcvPB | Hore_21030 | Hore_23410 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.980 |
ACL70848.1 | gcvT | Hore_21030 | Hore_23440 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.998 |
ACL70848.1 | glyA | Hore_21030 | Hore_16130 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.976 |
ACL70848.1 | purQ | Hore_21030 | Hore_22140 | Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase; Glucose inhibited division protein A; Biotin-requiring enzyme; FAD binding domain; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.828 |