node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroB | aroC | BCI_0023 | BCI_0361 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.939 |
aroB | hisC | BCI_0023 | BCI_0403 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.633 |
aroB | hisI | BCI_0023 | BCI_0398 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | phosphoribosyl-AMP cyclohydrolase; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family. | 0.537 |
aroC | aroB | BCI_0361 | BCI_0023 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. | 0.939 |
aroC | hisB | BCI_0361 | BCI_0402 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.449 |
aroC | hisC | BCI_0361 | BCI_0403 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.684 |
aroC | hisD | BCI_0361 | BCI_0404 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.431 |
aspC | hisC | BCI_0407 | BCI_0403 | Aspartate aminotransferase; Identified by match to protein family HMM PF00155. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.918 |
hisA | hisB | BCI_0400 | BCI_0402 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC | BCI_0400 | BCI_0403 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.987 |
hisA | hisD | BCI_0400 | BCI_0404 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.992 |
hisA | hisF | BCI_0400 | BCI_0399 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | BCI_0400 | BCI_0405 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.989 |
hisA | hisH | BCI_0400 | BCI_0401 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BCI_0400 | BCI_0398 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | phosphoribosyl-AMP cyclohydrolase; Identified by match to protein family HMM PF01502; match to protein family HMM PF01503; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | aroC | BCI_0402 | BCI_0361 | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.449 |
hisB | hisA | BCI_0402 | BCI_0400 | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Identified by match to protein family HMM PF00977; match to protein family HMM TIGR00007. | 0.999 |
hisB | hisC | BCI_0402 | BCI_0403 | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BCI_0402 | BCI_0404 | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | BCI_0402 | BCI_0399 | Histidinol-phosphatase/imidazoleglycerol- phosphate dehydratase; Identified by match to protein family HMM PF00475; match to protein family HMM TIGR01261; match to protein family HMM TIGR01656; match to protein family HMM TIGR01662; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |