node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fjoh_0217 | Fjoh_1712 | Fjoh_0217 | Fjoh_1712 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | 0.547 |
Fjoh_0217 | hisA | Fjoh_0217 | Fjoh_2873 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.881 |
Fjoh_0217 | hisB | Fjoh_0217 | Fjoh_2875 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.998 |
Fjoh_0217 | hisC | Fjoh_0217 | Fjoh_2876 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.921 |
Fjoh_0217 | hisD | Fjoh_0217 | Fjoh_2877 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.932 |
Fjoh_0217 | hisF | Fjoh_0217 | Fjoh_2872 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.908 |
Fjoh_0217 | hisG | Fjoh_0217 | Fjoh_2878 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.868 |
Fjoh_0217 | hisH | Fjoh_0217 | Fjoh_2874 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.888 |
Fjoh_0217 | hisI | Fjoh_0217 | Fjoh_2871 | PFAM: aminotransferase, class V; aminotransferase, class I and II. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.986 |
Fjoh_1712 | Fjoh_0217 | Fjoh_1712 | Fjoh_0217 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | PFAM: aminotransferase, class V; aminotransferase, class I and II. | 0.547 |
Fjoh_1712 | hisA | Fjoh_1712 | Fjoh_2873 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.725 |
Fjoh_1712 | hisB | Fjoh_1712 | Fjoh_2875 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.835 |
Fjoh_1712 | hisC | Fjoh_1712 | Fjoh_2876 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | Aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.547 |
Fjoh_1712 | hisD | Fjoh_1712 | Fjoh_2877 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.698 |
Fjoh_1712 | hisF | Fjoh_1712 | Fjoh_2872 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.785 |
Fjoh_1712 | hisG | Fjoh_1712 | Fjoh_2878 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.438 |
Fjoh_1712 | hisH | Fjoh_1712 | Fjoh_2874 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.725 |
Fjoh_1712 | hisI | Fjoh_1712 | Fjoh_2871 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; HAD-superfamily hydrolase, subfamily IB hypothetical 1; Haloacid dehalogenase domain protein hydrolase, type 3. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.961 |
guaA | hisA | Fjoh_2377 | Fjoh_2873 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein. | 0.836 |
guaA | hisB | Fjoh_2377 | Fjoh_2875 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; PFAM: imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.469 |