node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHGG_01676 | CHGG_03212 | Q2HDM8 | Q2H992 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | Uncharacterized protein. | 0.461 |
CHGG_01676 | CHGG_07366 | Q2HDM8 | Q2GXD8 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | Endo/exonuclease/phosphatase domain-containing protein. | 0.400 |
CHGG_01676 | CHGG_07367 | Q2HDM8 | Q2GXD7 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | Uncharacterized protein. | 0.400 |
CHGG_01676 | CHGG_07742 | Q2HDM8 | Q2GWB2 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | 5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. | 0.652 |
CHGG_01676 | CHGG_08971 | Q2HDM8 | Q2GST3 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | Uncharacterized protein. | 0.586 |
CHGG_01676 | FAL1 | Q2HDM8 | Q2GWJ5 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. | 0.845 |
CHGG_01676 | PAB1 | Q2HDM8 | Q2GSX8 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] | 0.975 |
CHGG_01676 | PAN2 | Q2HDM8 | Q2GSV2 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] | 0.601 |
CHGG_01676 | PAN3 | Q2HDM8 | Q2H401 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | 0.609 |
CHGG_01676 | TIF1 | Q2HDM8 | Q2HFP1 | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.971 |
CHGG_03212 | CHGG_01676 | Q2H992 | Q2HDM8 | Uncharacterized protein. | Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. | 0.461 |
CHGG_03212 | CHGG_07366 | Q2H992 | Q2GXD8 | Uncharacterized protein. | Endo/exonuclease/phosphatase domain-containing protein. | 0.961 |
CHGG_03212 | CHGG_07367 | Q2H992 | Q2GXD7 | Uncharacterized protein. | Uncharacterized protein. | 0.961 |
CHGG_03212 | CHGG_07742 | Q2H992 | Q2GWB2 | Uncharacterized protein. | 5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. | 0.531 |
CHGG_03212 | CHGG_08971 | Q2H992 | Q2GST3 | Uncharacterized protein. | Uncharacterized protein. | 0.998 |
CHGG_03212 | FAL1 | Q2H992 | Q2GWJ5 | Uncharacterized protein. | ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily. | 0.430 |
CHGG_03212 | PAB1 | Q2H992 | Q2GSX8 | Uncharacterized protein. | Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] | 0.762 |
CHGG_03212 | PAN2 | Q2H992 | Q2GSV2 | Uncharacterized protein. | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] | 0.584 |
CHGG_03212 | PAN3 | Q2H992 | Q2H401 | Uncharacterized protein. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] | 0.547 |
CHGG_03212 | TIF1 | Q2H992 | Q2HFP1 | Uncharacterized protein. | ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). | 0.435 |