node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | purA | AHA_2210 | AHA_3113 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.659 |
apt | purB | AHA_2210 | AHA_1413 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.959 |
apt | purD | AHA_2210 | AHA_0840 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.702 |
apt | purF | AHA_2210 | AHA_1870 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.452 |
apt | purH | AHA_2210 | AHA_0841 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.982 |
apt | purK | AHA_2210 | AHA_0069 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.789 |
apt | purM | AHA_2210 | AHA_2821 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. | 0.753 |
apt | purN | AHA_2210 | AHA_2822 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.488 |
fhs | glyA | AHA_1604 | AHA_3336 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.973 |
fhs | purB | AHA_1604 | AHA_1413 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.610 |
fhs | purD | AHA_1604 | AHA_0840 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.704 |
fhs | purF | AHA_1604 | AHA_1870 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.783 |
fhs | purH | AHA_1604 | AHA_0841 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional purine biosynthesis protein PurH; Identified by match to protein family HMM PF01808; match to protein family HMM PF02142; match to protein family HMM TIGR00355. | 0.984 |
fhs | purK | AHA_1604 | AHA_0069 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.454 |
fhs | purM | AHA_1604 | AHA_2821 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine cyclo-ligase; Identified by match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR00878. | 0.481 |
fhs | purN | AHA_1604 | AHA_2822 | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.969 |
glyA | fhs | AHA_3336 | AHA_1604 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Formate--tetrahydrofolate ligase; Identified by match to protein family HMM PF01268; Belongs to the formate--tetrahydrofolate ligase family. | 0.973 |
glyA | purA | AHA_3336 | AHA_3113 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.821 |
glyA | purB | AHA_3336 | AHA_1413 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.826 |
glyA | purD | AHA_3336 | AHA_0840 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoribosylamine--glycine ligase; Identified by match to protein family HMM PF01071; match to protein family HMM PF02655; match to protein family HMM PF02843; match to protein family HMM PF02844; match to protein family HMM TIGR00877; Belongs to the GARS family. | 0.836 |