node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_4146 | gntY | AHA_4146 | AHA_0297 | Hypothetical chaperone protein YegD. | Protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.588 |
AHA_4146 | hscB | AHA_4146 | AHA_1750 | Hypothetical chaperone protein YegD. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.690 |
AHA_4146 | iscS | AHA_4146 | AHA_1747 | Hypothetical chaperone protein YegD. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.422 |
AHA_4146 | iscU | AHA_4146 | AHA_1748 | Hypothetical chaperone protein YegD. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.829 |
cyaY | fdx | AHA_0472 | AHA_1752 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Ferredoxin, 2Fe-2S type, ISC system; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.888 |
cyaY | gntY | AHA_0472 | AHA_0297 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.670 |
cyaY | hscA | AHA_0472 | AHA_1751 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe-S protein assembly chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. | 0.778 |
cyaY | hscB | AHA_0472 | AHA_1750 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.827 |
cyaY | iscA | AHA_0472 | AHA_1749 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.774 |
cyaY | iscS | AHA_0472 | AHA_1747 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.985 |
cyaY | iscU | AHA_0472 | AHA_1748 | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.992 |
dnaK | fdx | AHA_2983 | AHA_1752 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ferredoxin, 2Fe-2S type, ISC system; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | 0.667 |
dnaK | gntY | AHA_2983 | AHA_0297 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.588 |
dnaK | hscB | AHA_2983 | AHA_1750 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Fe-S protein assembly co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.830 |
dnaK | iscA | AHA_2983 | AHA_1749 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Iron-sulfur cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family. | 0.579 |
dnaK | iscS | AHA_2983 | AHA_1747 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.670 |
dnaK | iscU | AHA_2983 | AHA_1748 | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | FeS cluster assembly scaffold IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.877 |
fdx | cyaY | AHA_1752 | AHA_0472 | Ferredoxin, 2Fe-2S type, ISC system; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. | 0.888 |
fdx | dnaK | AHA_1752 | AHA_2983 | Ferredoxin, 2Fe-2S type, ISC system; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.667 |
fdx | gntY | AHA_1752 | AHA_0297 | Ferredoxin, 2Fe-2S type, ISC system; Identified by match to protein family HMM PF00111; match to protein family HMM TIGR02007. | Protein GntY; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.658 |