node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_1610 | selA | AHA_1610 | AHA_2508 | SelT/selW/selH domain; Identified by match to protein family HMM PF05169; match to protein family HMM TIGR02174. | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | 0.555 |
AHA_1610 | selD | AHA_1610 | AHA_2224 | SelT/selW/selH domain; Identified by match to protein family HMM PF05169; match to protein family HMM TIGR02174. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.572 |
AHA_2221 | selD | AHA_2221 | AHA_2224 | Identified by match to protein family HMM PF00753. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.695 |
AHA_2221 | selU | AHA_2221 | AHA_2223 | Identified by match to protein family HMM PF00753. | tRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.702 |
AHA_3916 | selB | AHA_3916 | AHA_2509 | Pyridoxal phosphate-dependent enzyme, putative; Identified by match to protein family HMM PF01212; match to protein family HMM PF03841; match to protein family HMM TIGR01437. | Selenocysteine-specific translation elongation factor; Identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475. | 0.440 |
AHA_3916 | selD | AHA_3916 | AHA_2224 | Pyridoxal phosphate-dependent enzyme, putative; Identified by match to protein family HMM PF01212; match to protein family HMM PF03841; match to protein family HMM TIGR01437. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.921 |
AHA_4239 | iscS | AHA_4239 | AHA_1747 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.606 |
AHA_4239 | selD | AHA_4239 | AHA_2224 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.912 |
AHA_4239 | trxB | AHA_4239 | AHA_1863 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Thioredoxin-disulfide reductase; Identified by match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292. | 0.929 |
AHA_4239 | tusA | AHA_4239 | AHA_0133 | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | Conserved hypothetical protein; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.597 |
iscS | AHA_4239 | AHA_1747 | AHA_4239 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. | 0.606 |
iscS | selD | AHA_1747 | AHA_2224 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.879 |
iscS | tusA | AHA_1747 | AHA_0133 | Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | Conserved hypothetical protein; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family. | 0.981 |
selA | AHA_1610 | AHA_2508 | AHA_1610 | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | SelT/selW/selH domain; Identified by match to protein family HMM PF05169; match to protein family HMM TIGR02174. | 0.555 |
selA | selB | AHA_2508 | AHA_2509 | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | Selenocysteine-specific translation elongation factor; Identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475. | 0.983 |
selA | selD | AHA_2508 | AHA_2224 | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.952 |
selA | selU | AHA_2508 | AHA_2223 | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | tRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain. | 0.502 |
selB | AHA_3916 | AHA_2509 | AHA_3916 | Selenocysteine-specific translation elongation factor; Identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475. | Pyridoxal phosphate-dependent enzyme, putative; Identified by match to protein family HMM PF01212; match to protein family HMM PF03841; match to protein family HMM TIGR01437. | 0.440 |
selB | selA | AHA_2509 | AHA_2508 | Selenocysteine-specific translation elongation factor; Identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475. | L-seryl-tRNA selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. | 0.983 |
selB | selD | AHA_2509 | AHA_2224 | Selenocysteine-specific translation elongation factor; Identified by match to protein family HMM PF00009; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00475. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.907 |