STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
AHA_2515
Hydrogenase nickel incorporation protein HypB; Identified by match to protein family HMM PF02492; match to protein family HMM TIGR00073.
 
 
 0.992
hypC
Hydrogenase assembly chaperone HypC/HupF; Identified by match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.980
hypD
Hydrogenase expression/formation protein HypD; Identified by match to protein family HMM PF01924; match to protein family HMM TIGR00075; Belongs to the HypD family.
 
  
 0.980
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P40595; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
  
 0.978
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.977
hybC
Hydrogenase-2 large chain; Identified by similarity to SP:P37181; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.958
hybD
Hydrogenase expression/formation protein; Identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072; match to protein family HMM TIGR00140; match to protein family HMM TIGR00141.
 
  
 0.853
AHA_2526
Hydrogenase (NiFe) small subunit (hydA); Identified by similarity to SP:P18637; match to protein family HMM PF01058; match to protein family HMM TIGR00391; match to protein family HMM TIGR01409.
 
  
 0.848
HycE
Hydrogenase-4 component G; Identified by match to protein family HMM PF00329; match to protein family HMM PF00346.
 
 
 0.831
AHA_2504
Hydrogenase-4 component I; Identified by match to protein family HMM PF01058.
 
  
 0.780
Your Current Organism:
Aeromonas hydrophila
NCBI taxonomy Id: 380703
Other names: A. hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila ATCC 7966, Aeromonas hydrophila subsp. hydrophila str. ATCC 7966, Aeromonas hydrophila subsp. hydrophila strain ATCC 7966
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