node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_3407 | cysG1 | AHA_3407 | AHA_2578 | Nitrite reductase [NAD(P)H] large subunit; Identified by match to protein family HMM PF00355; match to protein family HMM TIGR02378. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.871 |
AHA_3407 | cysG2 | AHA_3407 | AHA_3568 | Nitrite reductase [NAD(P)H] large subunit; Identified by match to protein family HMM PF00355; match to protein family HMM TIGR02378. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.871 |
AHA_3407 | cysG3 | AHA_3407 | AHA_4121 | Nitrite reductase [NAD(P)H] large subunit; Identified by match to protein family HMM PF00355; match to protein family HMM TIGR02378. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.873 |
AHA_3407 | cysI | AHA_3407 | AHA_3372 | Nitrite reductase [NAD(P)H] large subunit; Identified by match to protein family HMM PF00355; match to protein family HMM TIGR02378. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.446 |
AHA_3407 | hemC | AHA_3407 | AHA_0469 | Nitrite reductase [NAD(P)H] large subunit; Identified by match to protein family HMM PF00355; match to protein family HMM TIGR02378. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.454 |
AHA_4157 | cysD | AHA_4157 | AHA_3567 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.963 |
AHA_4157 | cysG1 | AHA_4157 | AHA_2578 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.840 |
AHA_4157 | cysG2 | AHA_4157 | AHA_3568 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.840 |
AHA_4157 | cysG3 | AHA_4157 | AHA_4121 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.840 |
AHA_4157 | cysH | AHA_4157 | AHA_3373 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.961 |
AHA_4157 | cysI | AHA_4157 | AHA_3372 | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.830 |
cysC | cysD | AHA_3564 | AHA_3567 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.998 |
cysC | cysG1 | AHA_3564 | AHA_2578 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.830 |
cysC | cysG2 | AHA_3564 | AHA_3568 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.879 |
cysC | cysG3 | AHA_3564 | AHA_4121 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.830 |
cysC | cysH | AHA_3564 | AHA_3373 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.985 |
cysC | cysI | AHA_3564 | AHA_3372 | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.884 |
cysD | AHA_4157 | AHA_3567 | AHA_4157 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Adenylyl-sulfate kinase; Identified by match to protein family HMM PF01583; Belongs to the APS kinase family. | 0.963 |
cysD | cysC | AHA_3567 | AHA_3564 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. | 0.998 |
cysD | cysG1 | AHA_3567 | AHA_2578 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.840 |