node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_0892 | AHA_1665 | AHA_0892 | AHA_1665 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | 0.757 |
AHA_0892 | AHA_1740 | AHA_0892 | AHA_1740 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Lipoprotein NlpI; May be involved in cell division. | 0.767 |
AHA_0892 | lptC | AHA_0892 | AHA_3926 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.770 |
AHA_0892 | metJ | AHA_0892 | AHA_0588 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.760 |
AHA_0892 | mutH | AHA_0892 | AHA_0671 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | DNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.742 |
AHA_0892 | proQ | AHA_0892 | AHA_2292 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.768 |
AHA_0892 | rraB | AHA_0892 | AHA_3470 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.773 |
AHA_0892 | seqA | AHA_0892 | AHA_1536 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.765 |
AHA_0892 | syd | AHA_0892 | AHA_1158 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Syd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.748 |
AHA_0892 | yihI | AHA_0892 | AHA_0270 | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | Protein of unknown function; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.781 |
AHA_1665 | AHA_0892 | AHA_1665 | AHA_0892 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Conserved hypothetical protein; Identified by match to protein family HMM PF04217. | 0.757 |
AHA_1665 | AHA_1740 | AHA_1665 | AHA_1740 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Lipoprotein NlpI; May be involved in cell division. | 0.751 |
AHA_1665 | lptC | AHA_1665 | AHA_3926 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. | 0.735 |
AHA_1665 | metJ | AHA_1665 | AHA_0588 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Met repressor; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | 0.752 |
AHA_1665 | mutH | AHA_1665 | AHA_0671 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | DNA mismatch repair endonuclease MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family. | 0.669 |
AHA_1665 | proQ | AHA_1665 | AHA_2292 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | ProP effector; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.747 |
AHA_1665 | rraB | AHA_1665 | AHA_3470 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.768 |
AHA_1665 | seqA | AHA_1665 | AHA_1536 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.774 |
AHA_1665 | syd | AHA_1665 | AHA_1158 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Syd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family. | 0.627 |
AHA_1665 | yihI | AHA_1665 | AHA_0270 | Conserved hypothetical protein; Identified by match to protein family HMM PF07208; Belongs to the UPF0352 family. | Protein of unknown function; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. | 0.750 |