node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHA_0467 | cobA | AHA_0467 | AHA_3413 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.901 |
AHA_0467 | cysG1 | AHA_0467 | AHA_2578 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.535 |
AHA_0467 | cysG2 | AHA_0467 | AHA_3568 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
AHA_0467 | cysG3 | AHA_0467 | AHA_4121 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
AHA_0467 | hemC | AHA_0467 | AHA_0469 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.882 |
AHA_0467 | hemD | AHA_0467 | AHA_0468 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.994 |
AHA_0467 | hemE | AHA_0467 | AHA_0778 | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.908 |
cobA | AHA_0467 | AHA_3413 | AHA_0467 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Putative uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF04375. | 0.901 |
cobA | cysD | AHA_3413 | AHA_3567 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | 0.564 |
cobA | cysG1 | AHA_3413 | AHA_2578 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.725 |
cobA | cysG2 | AHA_3413 | AHA_3568 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.944 |
cobA | cysG3 | AHA_3413 | AHA_4121 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.945 |
cobA | cysH | AHA_3413 | AHA_3373 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.811 |
cobA | cysI | AHA_3413 | AHA_3372 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.817 |
cobA | hemC | AHA_3413 | AHA_0469 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.982 |
cobA | hemD | AHA_3413 | AHA_0468 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.918 |
cobA | hemE | AHA_3413 | AHA_0778 | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.914 |
cysD | cobA | AHA_3567 | AHA_3413 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | uroporphyrin-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.564 |
cysD | cysG1 | AHA_3567 | AHA_2578 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.840 |
cysD | cysG2 | AHA_3567 | AHA_3568 | Sulfate adenylyltransferase subunit 2; Identified by match to protein family HMM PF01507; match to protein family HMM TIGR02039. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.919 |