STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C5DN12_LACTCKLTH0G13310p. (664 aa)    
Predicted Functional Partners:
C5DL06_LACTC
KLTH0F08976p.
    
 0.884
C5DLY9_LACTC
Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.
   
 0.884
C5DHG2_LACTC
KLTH0E04092p.
   
 0.883
C5DH99_LACTC
KLTH0E02530p; Belongs to the PI3/PI4-kinase family.
    
 0.882
C5DMS9_LACTC
Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]
    
 0.879
C5E2D7_LACTC
KLTH0H04092p.
    
 0.877
C5E2T2_LACTC
KLTH0H07502p.
    
 0.837
C5DMQ0_LACTC
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
    
 0.809
C5E3C9_LACTC
KLTH0H12298p.
    
 0.796
C5E2J8_LACTC
KLTH0H05566p.
    
 0.792
Your Current Organism:
Lachancea thermotolerans
NCBI taxonomy Id: 559295
Other names: Kluyveromyces thermotolerans CBS 6340, L. thermotolerans CBS 6340, Lachancea thermotolerans CBS 6340
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.