STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhA1Pyruvate dehydrogenase complex, dehydrogenase (E1) component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)    
Predicted Functional Partners:
pdhL
Dihydrolipoamide dehydrogenase (E3) component ofpyruvate dehydrogenase.
 
 0.998
pdhB
Dihydrolipoamide acetyltransferase (E2) component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.997
bkdB
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase.
 
 0.975
acoC
Dihydrolipoamide S-acetyltransferase component of acetoin dehydrogenase complex; Dihydrolipoamide acetyltransferase involved in acetoin catabolism.
  
 0.966
maeB
Malic enzyme (NADP).
  
 
 0.961
maeA
Malic enzyme (NAD-binding).
  
 
 0.961
odhL
Dihydrolipoamide dehydrogenase (E3); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of 3 enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
 
 
 0.950
h16_B1098
Pyridinenucleotide-disulphide (lipoamid) oxidoreductase.
  
 
 0.943
pyk1
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.921
pyk2
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.921
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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