STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phaB1Acetoacetyl-CoA reductase; Catalyzes the chiral reduction of acetoacetyl-CoA to (R)-3-hydroxybutyryl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation (246 aa)    
Predicted Functional Partners:
phaC1
Poly(3-hydroxyalkanoate) polymerase subunit PhaC; Polymerizes (R)-3-hydroxybutyryl-CoA to create polyhydroxybutyrate (PHB) which consists of thousands of hydroxybutyrate molecules linked end to end. PHB serves as an intracellular energy reserve material when cells grow under conditions of nutrient limitation; Belongs to the PHA/PHB synthase family. Type I PhaC subfamily
 
  
 0.992
phaA
Acetyl-CoA acetyltransferase; Catalyzes the condensation of two acetyl-coA units to form acetoacetyl-CoA. Is involved in the biosynthesis of polyhydroxybutyrate (PHB), which is accumulated as an intracellular energy reserve material when cells grow under conditions of nutrient limitation. Also catalyzes the reverse reaction, i.e. the cleavage of acetoacetyl-CoA, and is therefore also involved in the reutilization of PHB
 
 0.992
phaC2
Poly(3-hydroxybutyrate) polymerase; Lipid metabolism
 
  
 0.972
bktB
Beta-ketothiolase BktB; Required for efficient production of poly(beta- hydroxybutyrate-co-beta-hydroxyvalerate) (PHBV). Catalyzes the condensation of acetyl-CoA and propionyl-CoA to form beta- ketovaleryl-CoA, and the condensation of two acetyl-CoA molecules to form acetoacetyl-CoA; Belongs to the thiolase family
 
 0.969
h16_A0170
Acetyl-CoA acetyltransferase; Lipid metabolism; Belongs to the thiolase family
 
 0.933
paaH1
3-Hydroxyacyl-CoA dehydrogenase; Lipid metabolism
  
 
 0.933
h16_A0461
Two domain protein: 3-hydroxyacyl-CoA dehydrogenase; Lipid metabolism
  
 0.932
h16_A1526
Enoyl-CoA hydratase/Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; Lipid metabolism
  
 0.932
h16_B0724
Enoyl-CoA hydratase/isomerase family; Lipid metabolism; Belongs to the enoyl-CoA hydratase/isomerase family
  
 0.932
h16_A0462
Acetyl-CoA C-acyltransferase; Lipid metabolism; Belongs to the thiolase family
 
 0.931
Your Current Organism:
Ralstonia eutropha H16
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, R. eutropha H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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