STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobT1Nicotinate-nucleotide-dimethylbenzimidazole (CobT); Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (346 aa)    
Predicted Functional Partners:
cobC
Alpha-ribazole phosphatase (CobC).
 
 
 0.996
cobU
Adenosylcobinamide-phosphate guanylyltransferase(CobU).
  
 0.994
cobS1
Cobalamin-5'-phosphate synthase (CobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.987
btuR
Cob(I)alamin adenosyltransferase (BtuR); Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.
 
   
 0.925
cbiP
Cobyric acid synthase (CbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.922
cobD
Cobalamin biosynthesis protein (CobD).
 
  
 0.860
cbiB
Cobalamin biosynthesis protein (CbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.835
btuC
ABC-type cobalamin transporter, permease component (BtuC); 8 TMHs; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
     
 0.747
btuD
ABC-type cobalamin transporter, ATPase component(BtuD).
     
 0.725
btuB
Outer membrane cobalamin receptor, TonB dependent(BtuB).
       0.684
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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