STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
h16_B0318Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of D-threonate to D-threonate 4-phosphate. Can also phosphorylate 4-hydroxy-L-threonine, with lower efficiency; Belongs to the four-carbon acid sugar kinase family. (415 aa)    
Predicted Functional Partners:
pdxA3
4-Hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-threonate 4-phosphate to produce dihydroxyacetone phosphate (DHAP). Can also use 4-hydroxy-L-threonine 4-phosphate as substrate.
     0.991
h16_B0317
2-Keto-3-deoxygluconate permease; The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system. Belongs to the KdgT transporter family.
 
   
 0.955
pdxA2
4-Hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family.
     0.933
pdxA1
4-Hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
     0.869
h16_A1560
Ribulose-5-phosphate 4-epimerase or related epimerase or aldolase; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2).
  
 0.814
h16_B0320
Transcriptional regulator, DeoR-family.
 
  
 0.637
hyi1
Hydroxypyruvate isomerase; Catalyzes the isomerization of 2-oxo-tetronate to 3-oxo- tetronate; Belongs to the hyi family. OtnI subfamily.
 
  
 0.538
hyi2
Hydroxypyruvate isomerase; Belongs to the hyi family.
 
  
 0.484
h16_A1562
3-Hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+); Belongs to the HIBADH-related family. L-threonate dehydrogenase subfamily.
 
  
 0.481
dapA2
Dihydrodipicolinate synthase; Belongs to the DapA family.
 
     0.432
Your Current Organism:
Cupriavidus necator
NCBI taxonomy Id: 381666
Other names: Alcaligenes eutropha H16, C. necator H16, Cupriavidus necator ATCC 17699, Cupriavidus necator H16, Ralstonia eutropha ATCC 17699, Ralstonia eutropha H16, Ralstonia eutropha str. H16, Ralstonia eutropha strain H16, Wautersia eutropha H16
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