STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fnod_1279PFAM: methylenetetrahydrofolate reductase; KEGG: sru:SRU_2094 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (313 aa)    
Predicted Functional Partners:
Fnod_0772
PFAM: dihydropteroate synthase DHPS; homocysteine S-methyltransferase; Methionine synthase B12-binding module cap domain protein; cobalamin B12-binding domain protein; KEGG: tma:TM0268 5-methyltetrahydrofolate S-homocysteine methyltransferase.
 
 
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.935
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.923
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.920
thyX
Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
     
 0.909
Fnod_1282
TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; KEGG: mka:MK0109 aspartokinase; Belongs to the aspartokinase family.
 
  
 0.813
Fnod_1278
PFAM: protein of unknown function DUF1063; KEGG: cbo:CBO2008 membrane protein; Belongs to the UPF0597 family.
       0.783
Fnod_0769
KEGG: tma:TM0269 hypothetical protein.
 
  
 0.756
Fnod_1281
Protein of unknown function DUF39; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF39; KEGG: mth:MTH855 inosine-5'-monophosphate dehydrogenase related protein VIII.
     
 0.753
Fnod_1280
PFAM: protein of unknown function DUF375; KEGG: sfu:Sfum_2124 protein of unknown function DUF375.
       0.702
Your Current Organism:
Fervidobacterium nodosum
NCBI taxonomy Id: 381764
Other names: F. nodosum Rt17-B1, Fervidobacterium nodosum Rt17-B1, Fervidobacterium nodosum str. Rt17-B1, Fervidobacterium nodosum strain Rt17-B1
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