STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 0.999
trpC
(Q9ZJU8) Tryptophan biosynthesis protein trpCF [Includes: Indole-3-glycerol phosphate synthase (EC 4.1.1.48) (IGPS); N-(5-phospho-ribosyl)anthranilate isomerase (EC 5.3.1.24) (PRAI)]; High confidence in function and specificity.
 
 0.999
trpD
Anthranilate phosphoribosyltransferase / anthranilate synthase component II; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
  
 0.997
trpE
(O25869) Anthranilate synthase component I (EC 4.1.3.27); High confidence in function and specificity.
 
  
 0.992
trpC-2
(Q9PI11) Indole-3-glycerol phosphate synthase (EC 4.1.1.48) (IGPS); High confidence in function and specificity.
  
 
 0.989
trpG
(O25868) Anthranilate synthase component II (EC 4.1.3.27) (Glutamine amido-transferase)Anthranilate synthase Chain B; High confidence in function and specificity.
 
  
 0.982
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.932
pabB
(P05041) Para-aminobenzoate synthase component I (EC 6.3.5.8) (ADC synthase)[EC:6.3.5.8 4.1.3.38]; High confidence in function and specificity.
  
  
 0.922
serB
SerB protein; (P44997) Phosphoserine phosphatase (EC 3.1.3.3) (PSP) (O-phosphoserine phosphohydrolase) (PSPase); High confidence in function and specificity.
   
 
 0.910
serB-2
SerB protein; (P44997) Phosphoserine phosphatase (EC 3.1.3.3) (PSP) (O-phosphoserine phosphohydrolase) (PSPase); High confidence in function and specificity.
   
 
 0.910
Your Current Organism:
Helicobacter acinonychis
NCBI taxonomy Id: 382638
Other names: H. acinonychis str. Sheeba, Helicobacter acinonychis Sheeba, Helicobacter acinonychis str. Sheeba, Helicobacter acinonychis strain Sheeba
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.