STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (385 aa)    
Predicted Functional Partners:
dcm
Site-specific DNA-methyltransferase; (P09795) Modification methylase SinI (EC 2.1.1.37) (Cytosine-specific methyltransferase SinI) (M.SinI); hypothetical protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.900
Hac_0360
DNA-cytosine methyltransferase.
    
 0.900
BSP6IM
C-5 cytosine-specific DNA methylase; (P34877) Modification methylase ScrFIA (EC 2.1.1.37) (Cytosine-specific methyltransferase ScrFIA) (M.ScrFIA) (M.ScrFI-A); High confidence in function and specificity.
    
 0.900
Hac_0966
Methylase; High confidence in function and specificity; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.900
Hac_1213
Site-specific DNA methyltransferase; (P08455) Modification methylase NgoPII (EC 2.1.1.37) (Cytosine-specific methyltransferase NgoPII) (M.NgoPII); High confidence in function and specificity.
    
 0.900
ribH
Riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
  
 
 0.853
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 
 0.804
tim
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
 
   
 0.777
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
  
 0.741
wbcJ
GDP-fucose synthetase, putative; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
   
 0.714
Your Current Organism:
Helicobacter acinonychis
NCBI taxonomy Id: 382638
Other names: H. acinonychis str. Sheeba, Helicobacter acinonychis Sheeba, Helicobacter acinonychis str. Sheeba, Helicobacter acinonychis strain Sheeba
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.