node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hac_1773 | Hac_1774 | Hac_1773 | Hac_1774 | Fibronectin/fibrinogen-binding protein. | Conserved hypothetical protein. | 0.773 |
Hac_1773 | ppnK | Hac_1773 | Hac_1771 | Fibronectin/fibrinogen-binding protein. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.764 |
Hac_1773 | recN | Hac_1773 | Hac_1772 | Fibronectin/fibrinogen-binding protein. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.851 |
Hac_1774 | Hac_1773 | Hac_1774 | Hac_1773 | Conserved hypothetical protein. | Fibronectin/fibrinogen-binding protein. | 0.773 |
Hac_1774 | ppnK | Hac_1774 | Hac_1771 | Conserved hypothetical protein. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.715 |
Hac_1774 | recN | Hac_1774 | Hac_1772 | Conserved hypothetical protein. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.771 |
cobT | nadD | Hac_0226 | Hac_0266 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphor; (O25849) NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog); High confidence in function and specificity; Belongs to the sirtuin family. Class III subfamily. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.936 |
cobT | nadE | Hac_0226 | Hac_0991 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphor; (O25849) NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog); High confidence in function and specificity; Belongs to the sirtuin family. Class III subfamily. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.922 |
cobT | ppnK | Hac_0226 | Hac_1771 | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphor; (O25849) NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog); High confidence in function and specificity; Belongs to the sirtuin family. Class III subfamily. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.920 |
dxs | ispD | Hac_0968 | Hac_1124 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | ispD/ispF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 0.843 |
dxs | ppnK | Hac_0968 | Hac_1771 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.685 |
dxs | tly | Hac_0968 | Hac_0796 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | Hemolysin; High confidence in function and specificity. | 0.438 |
ispD | dxs | Hac_1124 | Hac_0968 | ispD/ispF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.843 |
ispD | ppnK | Hac_1124 | Hac_1771 | ispD/ispF bifunctional enzyme; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF); In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.572 |
nadD | cobT | Hac_0266 | Hac_0226 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphor; (O25849) NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog); High confidence in function and specificity; Belongs to the sirtuin family. Class III subfamily. | 0.936 |
nadD | nadE | Hac_0266 | Hac_0991 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.953 |
nadD | ppnK | Hac_0266 | Hac_1771 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.940 |
nadD | surE | Hac_0266 | Hac_1085 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
nadE | cobT | Hac_0991 | Hac_0226 | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphor; (O25849) NAD-dependent deacetylase (EC 3.5.1.-) (Regulatory protein SIR2 homolog); High confidence in function and specificity; Belongs to the sirtuin family. Class III subfamily. | 0.922 |
nadE | nadD | Hac_0991 | Hac_0266 | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.953 |