node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rcas_0122 | Rcas_3878 | Rcas_0122 | Rcas_3878 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.498 |
Rcas_0122 | fhs | Rcas_0122 | Rcas_0522 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.943 |
Rcas_0122 | folD | Rcas_0122 | Rcas_0735 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
Rcas_0122 | gcvT | Rcas_0122 | Rcas_2285 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.933 |
Rcas_0122 | purH | Rcas_0122 | Rcas_4336 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | KEGG: rrs:RoseRS_0206 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.912 |
Rcas_0122 | purN | Rcas_0122 | Rcas_3176 | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.915 |
Rcas_3878 | Rcas_0122 | Rcas_3878 | Rcas_0122 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | 0.498 |
Rcas_3878 | fhs | Rcas_3878 | Rcas_0522 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.957 |
Rcas_3878 | folD | Rcas_3878 | Rcas_0735 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.622 |
Rcas_3878 | gcvT | Rcas_3878 | Rcas_2285 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.954 |
Rcas_3878 | glyA | Rcas_3878 | Rcas_1155 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
Rcas_3878 | purH | Rcas_3878 | Rcas_4336 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: rrs:RoseRS_0206 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.919 |
Rcas_3878 | purN | Rcas_3878 | Rcas_3176 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
fhs | Rcas_0122 | Rcas_0522 | Rcas_0122 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase; KEGG: rrs:RoseRS_4575 formiminotransferase-cyclodeaminase. | 0.943 |
fhs | Rcas_3878 | Rcas_0522 | Rcas_3878 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.957 |
fhs | folD | Rcas_0522 | Rcas_0735 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |
fhs | gcvT | Rcas_0522 | Rcas_2285 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.940 |
fhs | glyA | Rcas_0522 | Rcas_1155 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.965 |
fhs | purC | Rcas_0522 | Rcas_1843 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: SAICAR synthetase; KEGG: rrs:RoseRS_2552 phosphoribosylaminoimidazolesuccinocarboxamide synthase. | 0.877 |
fhs | purF | Rcas_0522 | Rcas_1511 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: rrs:RoseRS_0219 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. | 0.849 |