STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: rrs:RoseRS_1753 glutamate-1-semialdehyde-2,1-aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (434 aa)    
Predicted Functional Partners:
Rcas_2032
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: rrs:RoseRS_1752 porphobilinogen synthase; Belongs to the ALAD family.
 
 
 0.993
hemA
Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.985
Rcas_1491
TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: rrs:RoseRS_3469 malonyl CoA-acyl carrier protein transacylase.
    
 0.916
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.912
Rcas_0490
PFAM: AMP-dependent synthetase and ligase; KEGG: rrs:RoseRS_3648 AMP-dependent synthetase and ligase.
 
  
 0.849
Rcas_0776
PFAM: acylneuraminate cytidylyltransferase; KEGG: cth:Cthe_2230 acylneuraminate cytidylyltransferase.
      0.848
Rcas_2031
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.664
Rcas_0636
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: rrs:RoseRS_0573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
   
 0.578
Rcas_2034
KEGG: rrs:RoseRS_1755 hypothetical protein.
  
    0.532
Rcas_1775
PFAM: AMP-dependent synthetase and ligase; KEGG: rrs:RoseRS_2094 AMP-dependent synthetase and ligase.
 
  
 0.528
Your Current Organism:
Roseiflexus castenholzii
NCBI taxonomy Id: 383372
Other names: R. castenholzii DSM 13941, Roseiflexus castenholzii DSM 13941, Roseiflexus castenholzii HLO8, Roseiflexus castenholzii str. DSM 13941, Roseiflexus castenholzii strain DSM 13941
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