node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rcas_0633 | Rcas_3211 | Rcas_0633 | Rcas_3211 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | 0.629 |
Rcas_0633 | hisA | Rcas_0633 | Rcas_2920 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: rrs:RoseRS_3192 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.896 |
Rcas_0633 | hisB | Rcas_0633 | Rcas_3958 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rrs:RoseRS_1120 imidazoleglycerol-phosphate dehydratase. | 0.988 |
Rcas_0633 | hisD | Rcas_0633 | Rcas_2906 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.962 |
Rcas_0633 | hisF | Rcas_0633 | Rcas_2922 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.928 |
Rcas_0633 | hisG | Rcas_0633 | Rcas_2907 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.936 |
Rcas_0633 | hisH | Rcas_0633 | Rcas_2919 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.942 |
Rcas_0633 | hisI | Rcas_0633 | Rcas_4335 | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rrs:RoseRS_0207 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.995 |
Rcas_3211 | Rcas_0633 | Rcas_3211 | Rcas_0633 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_0576 aminotransferase, class I and II. | 0.629 |
Rcas_3211 | hisA | Rcas_3211 | Rcas_2920 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: rrs:RoseRS_3192 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.834 |
Rcas_3211 | hisB | Rcas_3211 | Rcas_3958 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rrs:RoseRS_1120 imidazoleglycerol-phosphate dehydratase. | 0.849 |
Rcas_3211 | hisC | Rcas_3211 | Rcas_0200 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: rrs:RoseRS_3872 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.629 |
Rcas_3211 | hisD | Rcas_3211 | Rcas_2906 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.740 |
Rcas_3211 | hisF | Rcas_3211 | Rcas_2922 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.881 |
Rcas_3211 | hisG | Rcas_3211 | Rcas_2907 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.568 |
Rcas_3211 | hisH | Rcas_3211 | Rcas_2919 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.833 |
Rcas_3211 | hisI | Rcas_3211 | Rcas_4335 | TIGRFAM: phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: rrs:RoseRS_3902 phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein. | PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: rrs:RoseRS_0207 phosphoribosyl-AMP cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.979 |
guaA | hisA | Rcas_1739 | Rcas_2920 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: rrs:RoseRS_3192 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.870 |
guaA | hisB | Rcas_1739 | Rcas_3958 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: rrs:RoseRS_1120 imidazoleglycerol-phosphate dehydratase. | 0.461 |
guaA | hisF | Rcas_1739 | Rcas_2922 | GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.520 |