node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pisl_0042 | Pisl_0115 | Pisl_0042 | Pisl_0115 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | 0.704 |
Pisl_0042 | Pisl_0116 | Pisl_0042 | Pisl_0116 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase. | 0.938 |
Pisl_0042 | Pisl_0179 | Pisl_0042 | Pisl_0179 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE2573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.629 |
Pisl_0042 | Pisl_0229 | Pisl_0042 | Pisl_0229 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | Protoporphyrin IX magnesium-chelatase; KEGG: mhu:Mhun_0291 magnesium chelatase, ChlI subunit; PFAM: magnesium chelatase, ChlI subunit; von Willebrand factor, type A; SMART: AAA ATPase. | 0.418 |
Pisl_0042 | hemA | Pisl_0042 | Pisl_0096 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.853 |
Pisl_0042 | hemC | Pisl_0042 | Pisl_0050 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.998 |
Pisl_0042 | hemL | Pisl_0042 | Pisl_0114 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pai:PAE0594 glutamate-1-semialdehyde aminotransferase (hemL); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.994 |
Pisl_0049 | Pisl_0051 | Pisl_0049 | Pisl_0051 | Conserved hypothetical protein; KEGG: pai:PAE2605 conserved within P.aerophilum. | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0579 metallo cofactor biosynthesis protein. | 0.773 |
Pisl_0049 | hemC | Pisl_0049 | Pisl_0050 | Conserved hypothetical protein; KEGG: pai:PAE2605 conserved within P.aerophilum. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.773 |
Pisl_0051 | Pisl_0049 | Pisl_0051 | Pisl_0049 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0579 metallo cofactor biosynthesis protein. | Conserved hypothetical protein; KEGG: pai:PAE2605 conserved within P.aerophilum. | 0.773 |
Pisl_0051 | hemC | Pisl_0051 | Pisl_0050 | PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: pai:PAE0579 metallo cofactor biosynthesis protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.817 |
Pisl_0115 | Pisl_0042 | Pisl_0115 | Pisl_0042 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | 0.704 |
Pisl_0115 | Pisl_0116 | Pisl_0115 | Pisl_0116 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase. | 0.987 |
Pisl_0115 | Pisl_0179 | Pisl_0115 | Pisl_0179 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE2573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.916 |
Pisl_0115 | hemA | Pisl_0115 | Pisl_0096 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.625 |
Pisl_0115 | hemC | Pisl_0115 | Pisl_0050 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.978 |
Pisl_0115 | hemL | Pisl_0115 | Pisl_0114 | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: pai:PAE0594 glutamate-1-semialdehyde aminotransferase (hemL); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. | 0.763 |
Pisl_0116 | Pisl_0042 | Pisl_0116 | Pisl_0042 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: pai:PAE0583 porphobilinogen synthase (delta-aminolevulinic acid dehydratase); Belongs to the ALAD family. | 0.938 |
Pisl_0116 | Pisl_0115 | Pisl_0116 | Pisl_0115 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase. | TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE0590 uroporphyrin-III C-methyltransferase. | 0.987 |
Pisl_0116 | Pisl_0179 | Pisl_0116 | Pisl_0179 | PFAM: Uroporphyrinogen III synthase HEM4; KEGG: pai:PAE0589 uroporphyrinogen-III synthase. | PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: pai:PAE2573 uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.935 |