STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (461 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate. Belongs to the LDH/MDH superfamily.
     
 0.919
Pisl_1888
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.919
Pisl_1106
PFAM: pyruvate kinase; KEGG: pai:PAE0819 pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.903
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
Pisl_1994
Formate dehydrogenase alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: pai:PAE2662 formate dehydrogenase alpha subunit.
  
  
  0.891
Pisl_1692
KEGG: pai:PAE1689 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
     
 0.837
Pisl_0160
KEGG: pai:PAE2660 formate dehydrogenase, cytochrome b556 subunit (formate dehydrogenase gamma subunit).
     
  0.800
Pisl_1343
PFAM: malate synthase; KEGG: pai:PAE1287 malate synthase.
     
  0.800
Pisl_1987
KEGG: hdu:HD1111 formate dehydrogenase, gamma subunit.
     
  0.800
Pisl_1995
Formate dehydrogenase beta subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: pai:PAE2661 formate dehydrogenase beta subunit.
     
  0.800
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.