STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lysZN-acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (261 aa)    
Predicted Functional Partners:
lysY
N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.
 
 0.999
Pisl_1455
PFAM: nitrogen regulatory protein P-II; KEGG: aae:aq_109 nitrogen regulatory PII protein; Belongs to the P(II) protein family.
   
 
 0.999
argH
PFAM: fumarate lyase; KEGG: pai:PAE2887 argininosuccinate lyase.
 
  
 0.990
Pisl_0279
PFAM: argininosuccinate synthase; KEGG: pai:PAE2884 argininosuccinate synthase.
  
  
 0.988
lysJ
N2-acetyl-L-lysine aminotransferase apoenzyme / acetylornithine aminotransferase apoenzyme; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily.
 
  
 0.983
Pisl_1291
L-2-aminoadipate N-acetyltransferase; TIGRFAM: alpha-L-glutamate ligases, RimK family; Lysine biosynthesis enzyme LysX; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: pai:PAE1240 ribosomal protein S6 modification protein.
 
  
 0.932
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
  
 0.930
carB
TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; KEGG: pai:PAE0947 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.
  
  
 0.898
carA
TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase, small chain; KEGG: pai:PAE0946 carbamoyl-phosphate synthase small subunit; Belongs to the CarA family.
  
  
 0.866
Pisl_0275
KEGG: pai:PAE2879 hypothetical protein.
       0.792
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.