STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Exhibits higher specific activity for oxaloacetate reduction than for malate oxidation in vitro. Has a strong preference for NAD. Can use NADPH for oxaloacetate reduction, but activity decreases more than 90%. No activity detected with NADP(+) and malate. Belongs to the LDH/MDH superfamily. (309 aa)    
Predicted Functional Partners:
Pisl_1692
KEGG: pai:PAE1689 citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase.
  
 0.997
Pisl_0950
Fumarase alpha subunit; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate alpha region; KEGG: pai:PAE2132 fumarate hydratase class I alpha subunit.
  
 
 0.982
Pisl_0951
Fumarase beta subunit; KEGG: pai:PAE2131 fumarate hydratase class I beta subunit; TIGRFAM: hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyases tartrate/fumarate beta region.
  
 
 0.982
Pisl_1672
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: pai:PAE1651 isocitrate dehydrogenase.
  
 
 0.981
Pisl_1343
PFAM: malate synthase; KEGG: pai:PAE1287 malate synthase.
   
 0.948
Pisl_1691
Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: pai:PAE1688 malate oxidoreductase (mae).
  
 0.946
Pisl_0770
PFAM: aminotransferase, class I and II; KEGG: pai:PAE2251 aspartate aminotransferase (aspC), conjectural.
  
 0.936
Pisl_1791
L-aspartate aminotransferase apoenzyme; PFAM: aminotransferase, class I and II; KEGG: pai:PAE1964 aspartate aminotransferase, conjectural.
  
 0.936
gap
KEGG: pai:PAE1740 glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: glyceraldehyde 3-phosphate dehydrogenase; dihydrodipicolinate reductase.
  
 
 0.927
ppcA
Phosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
     
 0.919
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
Server load: medium (78%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.