STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pisl_0811TIGRFAM: putative hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase, N-terminal domain; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal domain protein; KEGG: pai:PAE2185 3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (350 aa)    
Predicted Functional Partners:
Pisl_0813
KEGG: pai:PAE2183 acetyl-CoA C-acyltransferase.
 
 0.999
Pisl_0814
KEGG: pai:PAE2182 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase); TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family.
 
 0.999
Pisl_0812
PFAM: protein of unknown function DUF35; KEGG: pai:PAE2184 conserved protein associated with acetyl-CoA C-acyltransferase.
 
 
 0.998
Pisl_1437
PFAM: Thiolase; KEGG: pai:PAE1377 acetyl-CoA C-acyltransferase.
 
 0.997
Pisl_0029
KEGG: pai:PAE3656 acetyl-CoA C-acyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase.
  
 0.994
Pisl_1301
KEGG: pai:PAE1220 acetyl-CoA C-acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase.
  
 0.994
Pisl_1438
3-hydroxybutyryl-CoA epimerase; PFAM: protein of unknown function DUF35; 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase, NAD-binding; KEGG: pai:PAE1383 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase.
  
 
 0.972
Pisl_0497
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pai:PAE3279 2-ketoacid ferredoxin oxidoreductase gamma subunit.
    
 0.914
Pisl_1230
TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase; KEGG: pai:PAE1040 pyruvate ferredoxin oxidoreductase gamma subunit.
    
 0.914
Pisl_1662
Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: pai:PAE1638 putative transcriptional regulator.
 
    0.905
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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