node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pisl_0659 | Pisl_1152 | Pisl_0659 | Pisl_1152 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | 0.997 |
Pisl_0659 | pcn | Pisl_0659 | Pisl_0438 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.549 |
Pisl_0659 | pcn-2 | Pisl_0659 | Pisl_0667 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | Proliferating-cell nuclear antigen-like protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.659 |
Pisl_0659 | priL | Pisl_0659 | Pisl_0852 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.974 |
Pisl_0659 | priS | Pisl_0659 | Pisl_0437 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.937 |
Pisl_0659 | rnhB | Pisl_0659 | Pisl_1305 | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.734 |
Pisl_1152 | Pisl_0659 | Pisl_1152 | Pisl_0659 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | 0.997 |
Pisl_1152 | pcn | Pisl_1152 | Pisl_0438 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | 0.888 |
Pisl_1152 | pcn-2 | Pisl_1152 | Pisl_0667 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | Proliferating-cell nuclear antigen-like protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.851 |
Pisl_1152 | priL | Pisl_1152 | Pisl_0852 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.961 |
Pisl_1152 | priS | Pisl_1152 | Pisl_0437 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.930 |
Pisl_1152 | rnhB | Pisl_1152 | Pisl_1305 | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.768 |
Pisl_1739 | rnhB | Pisl_1739 | Pisl_1305 | PFAM: ribonuclease H; KEGG: pai:PAE1792 hypothetical protein. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.839 |
Pisl_2015 | rnhB | Pisl_2015 | Pisl_1305 | TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24, S26A and S26B; KEGG: pai:PAE0264 signal peptidase. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.823 |
carS | rnhB | Pisl_0708 | Pisl_1305 | Protein of unknown function DUF46; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. | RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.806 |
pcn | Pisl_0659 | Pisl_0438 | Pisl_0659 | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. | 0.549 |
pcn | Pisl_1152 | Pisl_0438 | Pisl_1152 | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | Replicative DNA helicase Mcm; PFAM: magnesium chelatase, ChlI subunit; MCM family protein; ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase; KEGG: pai:PAE0901 DNA replication licensing factor (mcm); Belongs to the MCM family. | 0.888 |
pcn | pcn-2 | Pisl_0438 | Pisl_0667 | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | Proliferating-cell nuclear antigen-like protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family. | 0.910 |
pcn | priL | Pisl_0438 | Pisl_0852 | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. | 0.920 |
pcn | priS | Pisl_0438 | Pisl_0437 | Monomeric archaeal DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] | 0.988 |