node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN2413 | PSEEN2414 | PSEEN2413 | PSEEN2414 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.993 |
PSEEN2413 | dinP | PSEEN2413 | PSEEN4107 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | DNA polymerase IV, damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. | 0.800 |
PSEEN2413 | lexA | PSEEN2413 | PSEEN3721 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.534 |
PSEEN2413 | recN | PSEEN2413 | PSEEN0776 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.446 |
PSEEN2414 | PSEEN2413 | PSEEN2414 | PSEEN2413 | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.993 |
PSEEN2414 | PSEEN3722 | PSEEN2414 | PSEEN3722 | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.404 |
PSEEN2414 | lexA | PSEEN2414 | PSEEN3721 | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.661 |
PSEEN2414 | recA | PSEEN2414 | PSEEN4128 | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.722 |
PSEEN2414 | recN | PSEEN2414 | PSEEN0776 | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.430 |
PSEEN3720 | PSEEN3722 | PSEEN3720 | PSEEN3722 | Putative transcriptional regulator, TetR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.546 |
PSEEN3720 | lexA | PSEEN3720 | PSEEN3721 | Putative transcriptional regulator, TetR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.600 |
PSEEN3722 | PSEEN2414 | PSEEN3722 | PSEEN2414 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Putative nucleotidyltransferase/DNA polymerase involved in DNA repair; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.404 |
PSEEN3722 | PSEEN3720 | PSEEN3722 | PSEEN3720 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Putative transcriptional regulator, TetR family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. | 0.546 |
PSEEN3722 | PSEEN4605 | PSEEN3722 | PSEEN4605 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | 0.813 |
PSEEN3722 | lexA | PSEEN3722 | PSEEN3721 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.887 |
PSEEN3722 | recA | PSEEN3722 | PSEEN4128 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.509 |
PSEEN3722 | recN | PSEEN3722 | PSEEN0776 | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.770 |
PSEEN4605 | PSEEN3722 | PSEEN4605 | PSEEN3722 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Putative cell division inhibitor-related protein, SulA-like; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.813 |
PSEEN4605 | lexA | PSEEN4605 | PSEEN3721 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | Transcriptional repressor for SOS response (signal peptidase of LexA family); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.570 |
PSEEN4605 | recA | PSEEN4605 | PSEEN4128 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function. | DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.; Belongs to the RecA family. | 0.465 |