node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
birA | guaA | lwe1923 | lwe1071 | Bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.568 |
birA | nadD | lwe1923 | lwe1501 | Bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.481 |
birA | nadE | lwe1923 | lwe1068 | Bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | NH(3)-dependent NAD(+) synthetases, nitrogen regulatory protein, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.564 |
birA | pncB | lwe1923 | lwe1067 | Bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.448 |
cinA | cobB | lwe1413 | lwe2687 | Competence/damage-inducible protein; Belongs to the CinA family. | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | 0.521 |
cinA | nadD | lwe1413 | lwe1501 | Competence/damage-inducible protein; Belongs to the CinA family. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.966 |
cinA | nadE | lwe1413 | lwe1068 | Competence/damage-inducible protein; Belongs to the CinA family. | NH(3)-dependent NAD(+) synthetases, nitrogen regulatory protein, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.544 |
cinA | pncB | lwe1413 | lwe1067 | Competence/damage-inducible protein; Belongs to the CinA family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.954 |
cobB | cinA | lwe2687 | lwe1413 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | Competence/damage-inducible protein; Belongs to the CinA family. | 0.521 |
cobB | nadD | lwe2687 | lwe1501 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.937 |
cobB | nadE | lwe2687 | lwe1068 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | NH(3)-dependent NAD(+) synthetases, nitrogen regulatory protein, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.927 |
cobB | nadK | lwe2687 | lwe0950 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.917 |
cobB | nadK-2 | lwe2687 | lwe1599 | Transcriptional regulator, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. | ATP-NAD kinase, putative; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.917 |
guaA | birA | lwe1071 | lwe1923 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.568 |
guaA | lwe1069 | lwe1071 | lwe1069 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Monooxygenase family protein. | 0.516 |
guaA | lwe1070 | lwe1071 | lwe1070 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | PTS system, IIB component, putative. | 0.507 |
guaA | nadE | lwe1071 | lwe1068 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | NH(3)-dependent NAD(+) synthetases, nitrogen regulatory protein, putative; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.700 |
guaA | pncB | lwe1071 | lwe1067 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.580 |
lwe1069 | guaA | lwe1069 | lwe1071 | Monooxygenase family protein. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.516 |
lwe1069 | lwe1070 | lwe1069 | lwe1070 | Monooxygenase family protein. | PTS system, IIB component, putative. | 0.670 |