node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
citZ | gsaB | lwe1580 | lwe1703 | Citrate synthase; Belongs to the citrate synthase family. | Glutamate-1-semialdehyde aminotransferase. | 0.468 |
citZ | hemL | lwe1580 | lwe1566 | Citrate synthase; Belongs to the citrate synthase family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.533 |
dltA | gsaB | lwe0956 | lwe1703 | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | Glutamate-1-semialdehyde aminotransferase. | 0.894 |
dltA | hemL | lwe0956 | lwe1566 | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.897 |
gsaB | citZ | lwe1703 | lwe1580 | Glutamate-1-semialdehyde aminotransferase. | Citrate synthase; Belongs to the citrate synthase family. | 0.468 |
gsaB | dltA | lwe1703 | lwe0956 | Glutamate-1-semialdehyde aminotransferase. | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] | 0.894 |
gsaB | hemA | lwe1703 | lwe1570 | Glutamate-1-semialdehyde aminotransferase. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.991 |
gsaB | hemB | lwe1703 | lwe1567 | Glutamate-1-semialdehyde aminotransferase. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.992 |
gsaB | hemC | lwe1703 | lwe1569 | Glutamate-1-semialdehyde aminotransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.958 |
gsaB | hemD | lwe1703 | lwe1158 | Glutamate-1-semialdehyde aminotransferase. | Uroporphyrinogen III synthase/methyltransferase. | 0.795 |
gsaB | hemD-2 | lwe1703 | lwe1568 | Glutamate-1-semialdehyde aminotransferase. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.825 |
gsaB | hemE | lwe1703 | lwe2229 | Glutamate-1-semialdehyde aminotransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.765 |
gsaB | hemL | lwe1703 | lwe1566 | Glutamate-1-semialdehyde aminotransferase. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.905 |
gsaB | lwe1099 | lwe1703 | lwe1099 | Glutamate-1-semialdehyde aminotransferase. | Siroheme synthase subunit family protein. | 0.533 |
hemA | gsaB | lwe1570 | lwe1703 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde aminotransferase. | 0.991 |
hemA | hemB | lwe1570 | lwe1567 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.988 |
hemA | hemC | lwe1570 | lwe1569 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
hemA | hemD | lwe1570 | lwe1158 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen III synthase/methyltransferase. | 0.956 |
hemA | hemD-2 | lwe1570 | lwe1568 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.987 |
hemA | hemE | lwe1570 | lwe2229 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.872 |