node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gmk | guaA | lwe1846 | lwe1071 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | 0.971 |
gmk | metK | lwe1846 | lwe1683 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.715 |
guaA | gmk | lwe1071 | lwe1846 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.971 |
guaA | lwe1696 | lwe1071 | lwe1696 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Homocysteine S-methyltransferase family/methylenetetrahydrofolate reductase family protein. | 0.628 |
guaA | metK | lwe1071 | lwe1683 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.741 |
guaA | purF | lwe1071 | lwe1786 | GMP synthetase; Catalyzes the synthesis of GMP from XMP. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.735 |
lcmA | metK | lwe0291 | lwe1683 | Cytosine methyl transferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.928 |
lwe0260 | lwe0838 | lwe0260 | lwe0838 | Aminotransferase, class I / II. | vitamin-B12 independent methionine synthase family protein. | 0.908 |
lwe0260 | lwe1608 | lwe0260 | lwe1608 | Aminotransferase, class I / II. | GAF domain protein. | 0.900 |
lwe0260 | lwe1696 | lwe0260 | lwe1696 | Aminotransferase, class I / II. | Homocysteine S-methyltransferase family/methylenetetrahydrofolate reductase family protein. | 0.957 |
lwe0260 | metE | lwe0260 | lwe1699 | Aminotransferase, class I / II. | Similar to 5-methyltetrahydrofolate-homocysteine methyltransferase (metH); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.909 |
lwe0260 | metK | lwe0260 | lwe1683 | Aminotransferase, class I / II. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.923 |
lwe0838 | lwe0260 | lwe0838 | lwe0260 | vitamin-B12 independent methionine synthase family protein. | Aminotransferase, class I / II. | 0.908 |
lwe0838 | lwe1608 | lwe0838 | lwe1608 | vitamin-B12 independent methionine synthase family protein. | GAF domain protein. | 0.900 |
lwe0838 | lwe1696 | lwe0838 | lwe1696 | vitamin-B12 independent methionine synthase family protein. | Homocysteine S-methyltransferase family/methylenetetrahydrofolate reductase family protein. | 0.998 |
lwe0838 | metE | lwe0838 | lwe1699 | vitamin-B12 independent methionine synthase family protein. | Similar to 5-methyltetrahydrofolate-homocysteine methyltransferase (metH); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.940 |
lwe0838 | metK | lwe0838 | lwe1683 | vitamin-B12 independent methionine synthase family protein. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.959 |
lwe1608 | lwe0260 | lwe1608 | lwe0260 | GAF domain protein. | Aminotransferase, class I / II. | 0.900 |
lwe1608 | lwe0838 | lwe1608 | lwe0838 | GAF domain protein. | vitamin-B12 independent methionine synthase family protein. | 0.900 |
lwe1608 | lwe1696 | lwe1608 | lwe1696 | GAF domain protein. | Homocysteine S-methyltransferase family/methylenetetrahydrofolate reductase family protein. | 0.904 |